Epithelial-to-mesenchymal transition, circulating tumor cells and cancer metastasis: Mechanisms and clinical applications.
Epithelial-to-mesenchymal transition, circulating tumor cells and cancer metastasis: Mechanisms and clinical applications.
复制标题
上皮间质转化、循环肿瘤细胞和癌症转移：机制和临床应用
DOI：
10.18632/oncotarget.18277
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发表时间：
2017-10-06
期刊：
影响因子：
--
通讯作者：
Xu CJ
中科院分区：
文献类型：
--
作者：
Jie XX;Zhang XY;Xu CJ
上皮细胞向间质细胞转化（Epithelial-to-mesenchymal transition，EMT）使上皮细胞具有更强的运动性和侵袭性，参与多种生理和病理过程。上皮-间质转化有助于上皮癌中循环肿瘤细胞（CTC）的产生，因为它增加肿瘤细胞侵袭性，促进肿瘤细胞内渗并确保肿瘤细胞在外周系统中存活。虽然上皮细胞向间质细胞转化对肿瘤细胞侵袭性的贡献已被证实，但上皮细胞向间质细胞转化在转移中所起的作用仍存在争议。循环肿瘤细胞作为一种良好的液体活检材料，在肿瘤的临床治疗中具有广阔的应用前景。此外，越来越多的研究开始探索CTC相关生物标志物的价值，一些研究发现，循环肿瘤细胞中EMT和干性标志物的表达，除了CTC检测外，还可以为肿瘤的诊断、治疗、预后和研究提供更多信息。
Epithelial-to-mesenchymal transition (EMT) endows epithelial cells with enhanced motility and invasiveness, allowing them to participate in many physiological and pathological processes. Epithelial-to-mesenchymal transition contributes to the generation of circulating tumor cells (CTCs) in epithelial cancers because it increases tumor cell invasiveness, promotes tumor cell intravasation and ensures tumor cell survival in the peripheral system. Although the contribution of epithelial-to-mesenchymal transition to tumor cell invasiveness has been confirmed, the role epithelial-to-mesenchymal transition plays in metastasis remains debated. As a favorable material for a “liquid biopsy”, circulating tumor cells have been shown to have promising values in the clinical management of tumors. Furthermore, an increasing number of studies have begun to explore the value of CTC-related biomarkers, and some studies have found that the expression of EMT and stemness markers in circulating tumor cells, in addition to CTC detection, can provide more information on tumor diagnosis, treatment, prognosis and research.
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