Bioelectric signaling in regeneration: Mechanisms of ionic controls of growth and form.
Bioelectric signaling in regeneration: Mechanisms of ionic controls of growth and form.
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DOI：
10.1016/j.ydbio.2017.08.032
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发表时间：
2018-01-15
影响因子：
2.7
通讯作者：
Levin M
中科院分区：
文献类型：
--
作者：
McLaughlin KA;Levin M
控制模式形成的能力对于复杂结构的胚胎发育以及对受损或缺失的组织和器官的再生/修复都是至关重要的。除了化学梯度和基因调控网络外，内源性离子流也是细胞行为的关键调控因素。生物电信号不仅为结构的初始发育提供了所需的信息，而且还使损伤后的正常模式得以稳健地恢复。为了扩大我们对负责复杂解剖修复的形态发生过程的基本理解，我们需要确定内源电压梯度、离子流和电场的作用。作为对目前对分子遗传学的关注的补充，解码由生物电线索传递的信息增强了我们对生长和图案形成的动态控制的知识。最近的科学和技术进步使我们处于一个令人兴奋的时刻，来阐明分子遗传输入和指导组织和器官创造的重要生物物理线索之间的相互作用。展望未来，这些新的见解使指导细胞行为的其他方法成为可能，并可能导致在增强再生能力方面取得深刻进展。
The ability to control pattern formation is critical for the both the embryonic development of complex structures as well as for the regeneration/repair of damaged or missing tissues and organs. In addition to chemical gradients and gene regulatory networks, endogenous ion flows are key regulators of cell behavior. Not only do bioelectric cues provide information needed for the initial development of structures, they also enable the robust restoration of normal pattern after injury. In order to expand our basic understanding of morphogenetic processes responsible for the repair of complex anatomy, we need to identify the roles of endogenous voltage gradients, ion flows, and electric fields. In complement to the current focus on molecular genetics, decoding the information transduced by bioelectric cues enhances our knowledge of the dynamic control of growth and pattern formation. Recent advances in science and technology place us in an exciting time to elucidate the interplay between molecular-genetic inputs and important biophysical cues that direct the creation of tissues and organs. Moving forward, these new insights enable additional approaches to direct cell behavior and may result in profound advances in augmentation of regenerative capacity.
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DOI：
10.2106/00004623-196143050-00002
发表时间：
1961-01-01
影响因子：
5.3
作者：
BECKER, RO
通讯作者：
BECKER, RO
影响因子：
1.6
作者：
BARTH, LJ;BARTH, LG
通讯作者：
BARTH, LG
影响因子：
2.7
作者：
Anderson, Ryan M.;Bosch, Justin A.;Goll, Mary G.;Hesselson, Daniel;Dong, P. Duc Si;Shin, Donghun;Chi, Neil C.;Shin, Chong Hyun;Schlegel, Amnon;Halpern, Marnie;Stainier, Didier Y. R.
通讯作者：
Stainier, Didier Y. R.
影响因子：
11.8
作者：
Beck, CW;Christen, B;Slack, JMW
通讯作者：
Slack, JMW
影响因子：
3.8
作者：
Bautista, Wendy;Lipschitz, Jeremy;Minuk, Gerald Y.
通讯作者：
Minuk, Gerald Y.