Intrachromosomal gene conversion and the maintenance of sequence homogeneity among repeated genes.
Intrachromosomal gene conversion and the maintenance of sequence homogeneity among repeated genes.
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染色体内基因转换和重复基因之间序列同质性的维持。
DOI：
10.1093/genetics/100.2.315
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发表时间：
1982
期刊：
影响因子：
3.3
通讯作者：
Petes,TD
中科院分区：
文献类型：
--
作者：
Nagylaki,T;Petes,TD
染色体内基因转换是指单个染色体上一对重复基因之间的非相互信息传递。这一过程最终在一个重复基因家族中产生序列同质性。单染色体谱系的进化模型制定和分析。表达式推导出固定概率，固定或丢失的平均时间，和平均条件固定时间的变异重复与任意的初始频率。结果表明，变异重复序列的小的转化优势或劣势（通过转化产生两个变异基因的概率高于或低于两个野生型基因）可以对固定的概率产生显著影响。这些结果表明，染色体内基因转换可以足够迅速地发挥作用，成为维持重复基因序列均一性的重要机制。
Intrachromosomal gene conversion is the non-reciprocal transfer of information between a pair of repeated genes on a single chromosome. This process produces eventual sequence homogeneity within a family of repeated genes. An evolutionary model for a single chromosome lineage was formulated and analyzed. Expressions were derived for the fixation probability, mean time to fixation or loss, and mean conditional fixation time for a variant repeat with an arbitrary initial frequency. It was shown that a small conversional advantage or disadvantage for the variant repeat (higher or lower probability of producing two variant genes by conversion than two wild-type genes) can have a dramatic effect on the probability of fixation. The results imply that intrachromosomal gene conversion can act sufficiently rapidly to be an important mechanism for maintaining sequence homogeneity among repeated genes.
影响因子：
64.8
作者：
JACKSON, JA;FINK, GR
通讯作者：
FINK, GR