Epigenetic modulation of visceral nociception.
Epigenetic modulation of visceral nociception.
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DOI：
10.1111/nmo.14443
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发表时间：
2022-09
影响因子：
3.5
通讯作者：
Verne, George Nicholas
中科院分区：
文献类型：
--
作者：
Zhou, QiQi;Verne, George Nicholas
关键词：
表观遗传学是一种改变基因活性或表型而不改变潜在DNA序列或基因类型的过程。这些生物变化可能会产生有害的影响，并可能导致各种人类疾病。正在进行的研究继续阐明表观遗传学在各种病理生理过程中的作用。已经研究了几类表观遗传机制，包括染色质重塑、DNA甲基化、组蛋白修饰和非编码RNA机制。这些表观遗传变化可以对基因表达产生长期影响，而不会对DNA序列产生任何潜在的变化。脑肠相互作用障碍和应激性内脏疼痛的潜在病理生理机制尚未完全了解，表观遗传机制在这些疾病中的作用正开始得到更好的理解。目前正在进行的工作是确定表观遗传学如何在慢性内脏疼痛和内脏伤害性感觉增强的患者的神经生物学中发挥作用。最近，动物模型和人类研究都显示了表观遗传调控如何调节应激诱导的内脏疼痛。虽然还需要更多的工作来完全阐明表观遗传学在慢性内脏伤害性感觉的神经生物学中的机制作用，但Louwies等人目前在神经胃肠病学和运动学上的研究提供了更多的证据，支持杏仁核中央核的表观遗传学改变参与了应激诱导的啮齿动物内脏高敏感性。
Epigenetics is a process that alters gene activity or phenotype without any changes in the underlying DNA sequence or genotype. These biological changes may have deleterious effects and can lead to various human diseases. Ongoing research is continuing to illuminate the role of epigenetics in a variety of pathophysiologic processes. Several categories of epigenetic mechanisms have been studied including chromatin remodeling, DNA methylation, histone modification, and non‐coding RNA mechanisms. These epigenetic changes can have a long‐term effect on gene expression without any underlying changes in the DNA sequences. The underlying pathophysiology of disorders of brain‐gut interaction and stress‐induced visceral pain are not fully understood and the role of epigenetic mechanisms in these disorders are starting to be better understood. Current work is underway to determine how epigenetics plays a role in the neurobiology of patients with chronic visceral pain and heightened visceral nociception. More recently, both animal models and human studies have shown how epigenetic regulation modulates stress‐induced visceral pain. While much more work is needed to fully delineate the mechanistic role of epigenetics in the neurobiology of chronic visceral nociception, the current study by Louwies et al., in Neurogastroenterology and Motility provides additional evidence supporting the involvement of epigenetic alterations in the central nucleus of the amygdala in stress‐induced visceral hypersensitivity in rodents.
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影响因子：
4
作者：
Fillingim, Roger B.;Bruehl, Stephen;Dworkin, Robert H.;Dworkin, Samuel F.;Loeser, John D.;Turk, Dennis C.;Widerstrom-Noga, Eva;Arnold, Lesley;Bennett, Robert;Edwards, Robert R.;Freeman, Roy;Gewandter, Jennifer;Hertz, Sharon;Hochberg, Marc;Krane, Elliot;Mantyh, Patrick W.;Markman, John;Neogi, Tuhina;Ohrbach, Richard;Paice, Judith A.;Porreca, Frank;Rappaport, Bob A.;Smith, Shannon M.;Smith, Thomas J.;Sullivan, Mark D.;Verne, G. Nicholas;Wasan, Ajay D.;Wesselmann, Ursula
通讯作者：
Wesselmann, Ursula
影响因子：
4
作者：
Fillingim, Roger B.;Loeser, John D.;Baron, Ralf;Edwards, Robert R.
通讯作者：
Edwards, Robert R.
DOI：
10.1038/nrgastro.2015.121
发表时间：
2015-10
期刊：
Nature reviews. Gastroenterology & hepatology
影响因子：
--
作者：
通讯作者：
--
影响因子：
29.4
作者：
Hong S;Zheng G;Wiley JW
通讯作者：
Wiley JW
影响因子：
105.7
作者：
Kaptchuk, Ted J.;Kelley, John M.;Lembo, Anthony J.
通讯作者：
Lembo, Anthony J.