Gastric alarmin release: A warning signal in the development of gastric mucosal diseases.
Gastric alarmin release: A warning signal in the development of gastric mucosal diseases.
复制标题
胃警报素释放：胃粘膜疾病发展的警告信号。
DOI：
10.3389/fimmu.2022.1008047
复制
发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
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作者：
损伤相关分子模式（Alarmins）存在于细胞外，是免疫系统的早期预警信号；因此，损伤相关分子模式受体广泛分布于各种免疫细胞上。损伤相关分子模式是与组织损伤相关的促炎分子模式，通常释放到细胞外空间，在那里它们诱导免疫反应，并参与黏膜疾病的损伤与修复过程。在胃部，胃内损伤相关分子模式的释放已被证明与胃黏膜炎症、抗菌防御、适应性免疫和伤口愈合有关；此外，这种释放会造成损伤，并导致胃黏膜疾病的发生，包括各类胃炎、溃疡和胃癌。因此，有必要了解损伤相关分子模式在胃黏膜疾病中的作用。本综述聚焦于包括白细胞介素33（IL33）、高迁移率族蛋白B1（HMGB1）、防御素和抗菌肽等损伤相关分子模式对胃黏膜屏障的作用及其在胃黏膜疾病中的角色。在此，我们为胃黏膜疾病的防治提供一个新视角。
Alarmins exist outside cells and are early warning signals to the immune system; as such, alarmin receptors are widely distributed on various immune cells. Alarmins, proinflammatory molecular patterns associated with tissue damage, are usually released into the extracellular space, where they induce immune responses and participate in the damage and repair processes of mucosal diseases.In the stomach, gastric alarmin release has been shown to be involved in gastric mucosal inflammation, antibacterial defense, adaptive immunity, and wound healing; moreover, this release causes damage and results in the development of gastric mucosal diseases, including various types of gastritis, ulcers, and gastric cancer. Therefore, it is necessary to understand the role of alarmins in gastric mucosal diseases. This review focuses on the contribution of alarmins, including IL33, HMGB1, defensins and cathelicidins, to the gastric mucosal barrier and their role in gastric mucosal diseases. Here, we offer a new perspective on the prevention and treatment of gastric mucosal diseases.
影响因子：
--
作者：
Hayashi H;Kawakita A;Okazaki S;Murai H;Yasutomi M;Ohshima Y
通讯作者：
Ohshima Y
影响因子：
2.9
作者：
Yang D;Oppenheim JJ
通讯作者：
Oppenheim JJ