IL-33 enhanced the proliferation and constitutive production of IL-13 and IL-5 by fibrocytes.
IL-33 enhanced the proliferation and constitutive production of IL-13 and IL-5 by fibrocytes.
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DOI：
10.1155/2014/738625
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发表时间：
2014
影响因子：
--
通讯作者：
Ohshima Y
中科院分区：
文献类型：
--
作者：
Hayashi H;Kawakita A;Okazaki S;Murai H;Yasutomi M;Ohshima Y
Interleukin-33 appears to play important roles in the induction of allergic airway inflammation. However, whether IL-33 is involved in airway remodeling remains unclear. Because fibrocytes contribute to tissue remodeling in the setting of chronic inflammation, we examined the effects of IL-33 on fibrocyte functions. Fibrocytes were generated in vitro from peripheral blood mononuclear cells by culturing in the presence of platelet derived growth factors and the cells were stimulated with IL-33. IL-33 enhanced cell proliferation, α-SMA expression, and pro-MMP-9 activity by the fibrocytes without increasing endogenous transforming growth factor-β1 production. Fibrocytes constitutively expressed IL-13 and IL-5, and their production was augmented by stimulation with IL-33. Dexamethasone inhibited the functions of fibrocytes, but IL-33 made fibrocytes slightly refractory to the inhibitory effect of dexamethasone in terms of IL-13 production. Montelukast suppressed IL-13 production by nonstimulated fibrocytes but not those stimulated by IL-33. These findings suggest that IL-33 is involved in the airway remodeling process through its modulation of fibrocyte function independent of antigen stimulation. IL-33 might partially reduce the therapeutic effects of glucocorticoid and cysteinyl leukotriene receptor antagonist on fibrocyte-mediated Th2 responses.
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DOI：
10.1038/nri2990
发表时间：
2011-06
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1016/j.bbrc.2006.11.149
发表时间：
2007-02-02
影响因子：
3.1
作者：
Mehrad, Borna;Burdick, Marie D.;Strieter, Robert M.
通讯作者：
Strieter, Robert M.
影响因子：
14.2
作者：
Semlali, Abdelhabib;Jacques, Eric;Chakir, Jamila
通讯作者：
Chakir, Jamila
影响因子：
14.2
作者：
Allakhverdi, Zoulfia;Comeau, Michael R.;Delespesse, Guy
通讯作者：
Delespesse, Guy
影响因子：
3.3
作者：
Sakai, Norihiko;Furuichi, Kengo;Wada, Takashi
通讯作者：
Wada, Takashi