Ski and SnoN, potent negative regulators of TGF-beta signaling.
Ski and SnoN, potent negative regulators of TGF-beta signaling.
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Ski和密切相关的SnoN被发现为癌基因，因为它们在过表达时能够转化鸡胚成纤维细胞。虽然在许多人类癌细胞和组织中也报道了Ski和SnoN的表达升高，与其促癌活性一致，但新出现的证据也表明两者都具有潜在的抗癌活性。此外，Ski和SnoN参与细胞分化的调节，特别是在肌肉和神经元谱系中。已经鉴定了Ski和SnoN的多个细胞伴侣，以努力理解Ski和SnoN复杂作用的分子机制。在这篇综述中，我们总结了最近的研究结果的生物学功能的滑雪和SnoN，他们的行动机制和他们的表达水平是如何调节。
Ski and the closely related SnoN were discovered as oncogenes by their ability to transform chicken embryo fibroblasts upon overexpression. While elevated expressions of Ski and SnoN have also been reported in many human cancer cells and tissues, consistent with their pro-oncogenic activity, emerging evidence also suggests a potential anti-oncogenic activity for both. In addition, Ski and SnoN have been implicated in regulation of cell differentiation, especially in the muscle and neuronal lineages. Multiple cellular partners of Ski and SnoN have been identified in an effort to understand the molecular mechanisms underlying the complex roles of Ski and SnoN. In this review, we summarize recent findings on the biological functions of Ski and SnoN, their mechanisms of action and how their levels of expression are regulated.
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