The neurovascular unit and combination treatment strategies for stroke.
The neurovascular unit and combination treatment strategies for stroke.
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DOI：
10.1016/j.tips.2012.04.006
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发表时间：
2012-08
影响因子：
13.8
通讯作者：
Chopp M
中科院分区：
文献类型：
--
作者：
Zhang L;Zhang ZG;Chopp M
Tissue plasminogen activator (tPA) administered within 4.5 hours of symptom onset restores cerebral blood flow and promotes neurological recovery of stroke patients. However, the narrow therapeutic time window and the risk of intracerebral hemorrhage after tPA treatment pose major hurdles to its clinical usage. In light of the failures of neuroprotective therapies in clinical trials, emerging concepts suggest that neuroprotection alone without restoration of tissue perfusion and vascular integrity may not be adequate for treatment of acute stroke. Here we review evidence of the use of adjuvant pharmacological agents to extend the therapeutic window for tPA via targeting the neurovascular unit and the underlying mechanisms of the combination therapy in experimental stroke.
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影响因子：
8.3
作者：
Alvarez-Sabin, Jose;Huertas, Rafael;Montaner, Joan
通讯作者：
Montaner, Joan
影响因子：
6.3
作者：
Brea, David;Blanco, Miguel;Castillo, Jose
通讯作者：
Castillo, Jose
影响因子：
37.8
作者：
Benchenane, K;Berezowski, V;Vivien, D
通讯作者：
Vivien, D
影响因子：
37.8
作者：
Caso, Javier R.;Pradillo, Jesus M.;Lizasoain, Ignacio
通讯作者：
Lizasoain, Ignacio
DOI：
10.1186/2040-7378-1-4
发表时间：
2009-10-21
期刊：
Experimental & translational stroke medicine
影响因子：
--
作者：
Byts N;Sirén AL
通讯作者：
Sirén AL