Untuned but not irrelevant: The role of untuned neurons in sensory information coding
Untuned but not irrelevant: The role of untuned neurons in sensory information coding
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未调谐但并非无关紧要：未调谐神经元在感觉信息编码中的作用
DOI：
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
J. Zylberberg
中科院分区：
文献类型：
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作者：
J. Zylberberg
在感觉系统中，大多数神经元的触发率至少是刺激的一个方面。忽略了未调节的神经元，基于默示的假设，即最近的实验工作已经质疑这一假设，表明在某些情况下，神经元没有明显的刺激调整对感官信息编码的贡献。由于调整较弱的调整，该神经元在人群编码上的未调节，但较低的实验人员将调用神经元调用的阈值（vs not tanded）？要在大脑中进行不调节的神经元？可以增强感官信息编码；某些带有未调节的神经元的调节。当在电路中具有未调节的神经元具有功能益处，因此提出了一个大脑可能包含未张开的神经元的原因。情况，某些神经元没有调节的情况，这些神经元仍然可以促进感官信息编码，因此不应被忽略。
In the sensory systems, most neurons’ firing rates are tuned to at least one aspect of the stimulus. Other neurons are appear to be untuned, meaning that their firing rates do not depend on the stimulus. Previous work on information coding in neural populations has ignored untuned neurons, based on the tacit assumption that they are unimportant. Recent experimental work has questioned this assumption, showing that in some circumstances, neurons with no apparent stimulus tuning can contribute to sensory information coding. These findings are intriguing, because they suggest that – by virtue of our ignoring putatively untuned neurons – our understanding of neural population coding might be incomplete. At the same time, several key questions remain unanswered: Are the impacts of putatively untuned neurons on population coding due to weak tuning that is nevertheless below the threshold the experimenters set for calling neurons tuned (vs untuned)? And why do there appear to be untuned neurons in the brain? Do mixed populations of tuned and untuned neurons have a functional advantage over populations containing only tuned neurons? Using theoretical calculations and analyses of in vivo neural data, I answer those questions by: a) showing how untuned neurons can enhance sensory information coding; b) demonstrating that this effect does not rely on weak tuning; and c) identifying conditions under which the neural code can be made more informative by replacing some of the tuned neurons with untuned ones. These conditions specify when there is a functional benefit to having untuned neurons in a circuit, and thus suggest a reason why the brain might contain untuned neurons. Overall, this work shows that, even in the extreme case, where some neurons have no tuning, those neurons can still contribute to sensory information coding, and thus should not be ignored.
影响因子：
16.2
作者：
Ecker AS;Berens P;Cotton RJ;Subramaniyan M;Denfield GH;Cadwell CR;Smirnakis SM;Bethge M;Tolias AS
通讯作者：
Tolias AS
影响因子：
2.5
作者：
Averbeck, Bruno B.;Lee, Daeyeol
通讯作者：
Lee, Daeyeol
DOI：
10.1016/j.jphysparis.2016.11.001
发表时间：
2016-11-01
期刊：
Journal of physiology, Paris
影响因子：
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作者：
Delhaye, Benoit P;Saal, Hannes P;Bensmaia, Sliman J
通讯作者：
Bensmaia, Sliman J