Anticedants and natural prevention of environmental toxicants induced accelerated aging of skin.
Anticedants and natural prevention of environmental toxicants induced accelerated aging of skin.
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环境毒物的预防剂和自然预防会导致皮肤加速老化。
DOI：
10.1016/j.etap.2014.11.003
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发表时间：
2015
影响因子：
4.3
通讯作者：
V. Rani
中科院分区：
文献类型：
--
作者：
Tanuja Yadav;Shivangi Mishra;Shefali Das;S. Aggarwal;V. Rani
皮肤经常暴露在各种环境和化学物质中，加速衰老。紫外线辐射(UVR)和环境污染物等外界应激主要通过激活某些内在因素，如活性氧物种(ROS)，触发基质金属蛋白酶(MMPs)的激活和炎症反应，从而破坏细胞外基质(ECM)成分，从而使皮肤形态恶化。为了应对这种情况，需要外源抗氧化剂，因为仅靠内源性抗氧化剂系统不能满足需要。因此，加强了对自然资源抗氧化剂的生物勘探。大量的研究正在进行，以确定潜在的植物具有强大的抗氧化活性，防止皮肤老化。该综述总结了导致皮肤过早老化的主要因素，以及针对哪些植物来减轻这些因素的影响。
Skin is frequently exposed to a variety of environmental and chemical agents that accelerate ageing. External stress such as UV radiations (UVR) and environmental pollutants majorly deteriorate the skin morphology, by activating certain intrinsic factors such as Reactive Oxygen Species (ROS) which trigger the activation of Matrix Metalloproteinases (MMPs) and inflammatory responses hence damaging the extracellular matrix (ECM) components. To counter this, an exogenous supply of anti-oxidants, is required since the endogenous anti-oxidant system cannot alone suffice the need. Bio-prospecting of natural resources for anti-oxidants has hence been intensified. Immense research is being carried out to identify potential plants with potent anti-oxidant activity against skin ageing. This review summarizes the major factors responsible for premature skin ageing and the plants being targeted to lessen the impact of those.
定义衰老的毒理学。
影响因子：
13.6
作者：
Sorrentino JA;Sanoff HK;Sharpless NE
通讯作者：
Sharpless NE
影响因子：
7.4
作者：
Zirnniak, Piotr
通讯作者：
Zirnniak, Piotr
影响因子：
3.5
作者：
Senthilkumar, P. K.;Klingelhutz, A. J.;Jacobus, J. A.;Lehmler, H.;Robertson, L. W.;Ludewig, G.
通讯作者：
Ludewig, G.