Global prevalence of visual impairment associated with myopic macular degeneration and temporal trends from 2000 through 2050: systematic review, meta-analysis and modelling.

Global prevalence of visual impairment associated with myopic macular degeneration and temporal trends from 2000 through 2050: systematic review, meta-analysis and modelling.
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DOI:
10.1136/bjophthalmol-2017-311266
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发表时间:
2018-07
期刊:
The British journal of ophthalmology
影响因子:
--
通讯作者:
Resnikoff S
Resnikoff S
中科院分区:
其他
文献类型:
--
作者:
Fricke TR;Jong M;Naidoo KS;Sankaridurg P;Naduvilath TJ;Ho SM;Wong TY;Resnikoff S

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我们使用系统回顾和荟萃分析来识别和吸收量化与近视黄斑变性 (MMD) 相关的失明和视力障碍 (VI) 的证据,然后导出模型来预测总体模式。这些模型用于估计 2000 年至 2050 年全球与 MMD 相关的失明和 VI 患病率。系统审查确定了 17 篇含有 MMD VI 患病率数据的论文,符合我们的纳入标准。来自六篇具有特定年龄数据的论文的数据被缩放到相对年龄依赖性风险,并在 VI 和失明水平上进行荟萃分析。我们根据数据收集地点和年份的变量,分析了所有 MMD VI 和失明数据的方差,即高度近视的比例,并使用基于医疗支出的模型提供了最佳相关性。我们使用此模型来估计每个国家每个十年内 MMD VI 的患病率和人数。我们纳入了 17 项研究的数据,涉及 137-514 名参与者。我们估计 2015 年有 1000 万人因 MMD 患有 VI(患病率 0.13%,95% CI 5.5 至 2370 万人,0.07% 至 0.34%),其中 330 万人失明(0.04%,1.8 至 780 万人,0.03% 至 0.10%)。我们估计,到 2050 年,在不改变现有干预措施的情况下,MMD 导致的 VI 人数将增至 5570 万人(0.57%、29.0 至 1.197 亿、0.33% 至 1.11%),其中 1850 万人将失明(0.19%、9.6 至 3970 万人、 0.11% 至 0.37%)。如果不努力减少近视的发生和进展并改善 MMD 的管理,MMD 失明和 VI 的负担将会显着增加。
We used systematic review and meta-analysis to identify and assimilate evidence quantifying blindness and visual impairment (VI) associated with myopic macular degeneration (MMD), then derived models to predict global patterns. The models were used to estimate the global prevalence of blindness and VI associated with MMD from 2000 to 2050. The systematic review identified 17 papers with prevalence data for MMD VI fitting our inclusion criteria. Data from six papers with age-specific data were scaled to relative age-dependent risk and meta-analysed at VI and blindness levels. We analysed variance in all MMD VI and blindness data as a proportion of high myopia against variables from the place and year of data collection, with a model based on health expenditure providing the best correlation. We used this model to estimate the prevalence and number of people with MMD VI in each country in each decade. We included data from 17 studies comprising 137 514 participants. We estimated 10.0 million people had VI from MMD in 2015 (prevalence 0.13%, 95% CI 5.5 to 23.7 million, 0.07% to 0.34%), 3.3 million of whom were blind (0.04%, 1.8 to 7.8 million, 0.03% to 0.10%). We estimate that by 2050, without changing current interventions, VI from MMD will grow to 55.7 million people (0.57%, 29.0 to 119.7 million, 0.33% to 1.11%), 18.5 million of whom will be blind (0.19%, 9.6 to 39.7 million, 0.11% to 0.37%). The burden of MMD blindness and VI will rise significantly without efforts to reduce the development and progression of myopia and improve the management of MMD.
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