Neutrophil-to-Lymphocyte Ratio Predicts Mortality in Adult Renal Transplant Recipients with Severe Community-Acquired Pneumonia.
Neutrophil-to-Lymphocyte Ratio Predicts Mortality in Adult Renal Transplant Recipients with Severe Community-Acquired Pneumonia.
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中性粒细胞与淋巴细胞比率可预测患有严重社区获得性肺炎的成人肾移植受者的死亡率
DOI：
10.3390/pathogens9110913
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发表时间：
2020-11-04
期刊：
影响因子：
--
通讯作者：
Luo Z
中科院分区：
文献类型：
--
作者：
Qiu Y;Su Y;Tu GW;Ju MJ;He HY;Gu ZY;Yang C;Luo Z
尽管重症监护管理取得了进展，但肾移植受者严重社区获得性肺炎（CAP）的死亡率仍然很高。仍然缺乏用于预测这些患者预后的生物标志物。本研究旨在探讨肾移植受者重症CAP患者嗜中性粒细胞/淋巴细胞比值（NLR）与死亡率之间的关系。在2009年1月1日至2018年11月30日期间，共对111名入住重症监护室（ICU）的重度CAP肾移植受者进行了资格筛选。回顾性收集患者特征和ICU入院时的实验室检查结果。最终入选的81例重度CAP患者中有18例（22.2%）死亡。非幸存者的NLR水平高于幸存者（26.8 vs. 12.3，p < 0.001）。根据曲线下面积，NLR预测死亡率的能力最大（0.88 ± 0.04; p < 0.0001）与血小板/淋巴细胞比值相比（0.75 ± 0.06; p < 0.01）、肺炎严重程度指数（0.65 ± 0.08; p = 0.05）、CURB-65（0.65 ± 0.08; p = 0.05）和中性粒细胞计数（0.68 ± 0.07; p < 0.01）。多因素logistic回归模型显示NLR与严重CAP肾移植受者的住院和ICU死亡率相关。NLR水平与死亡率独立相关，可能是预测严重CAP肾移植受者预后不良的有用生物标志物。
Mortality of renal transplant recipients with severe community-acquired pneumonia (CAP) remains high, despite advances in critical care management. There is still a lack of biomarkers for predicting prognosis of these patients. The present study aimed to investigate the association between neutrophil-to-lymphocyte ratio (NLR) and mortality in renal transplant recipients with severe CAP. A total of 111 renal transplant recipients with severe CAP admitted to the intensive care unit (ICU) were screened for eligibility between 1 January 2009 and 30 November 2018. Patient characteristics and laboratory test results at ICU admission were retrospectively collected. There were 18 non-survivors (22.2%) among 81 patients with severe CAP who were finally included. Non-survivors had a higher NLR level than survivors (26.8 vs. 12.3, p < 0.001). NLR had the greatest power to predict mortality as suggested by area under the curve (0.88 ± 0.04; p < 0.0001) compared to platelet-to-lymphocyte ratio (0.75 ± 0.06; p < 0.01), pneumonia severity index (0.65 ± 0.08; p = 0.05), CURB-65 (0.65 ± 0.08; p = 0.05), and neutrophil count (0.68 ± 0.07; p < 0.01). Multivariate logistic regression models revealed that NLR was associated with hospital and ICU mortality in renal transplant recipients with severe CAP. NLR levels were independently associated with mortality and may be a useful biomarker for predicting poor outcome in renal transplant recipients with severe CAP.
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影响因子：
17.7
作者：
Mackinnon, A;Mulligan, R
通讯作者：
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