Regulation of specific target genes and biological responses by estrogen receptor subtype agonists.
Regulation of specific target genes and biological responses by estrogen receptor subtype agonists.
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DOI：
10.1016/j.coph.2010.09.009
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发表时间：
2010-12
影响因子：
4
通讯作者：
Speed, Terence P.
中科院分区：
文献类型：
--
作者：
Leitman, Dale C.;Paruthiyil, Sreenivasan;Vivar, Omar I.;Saunier, Elise F.;Herber, Candice B.;Cohen, Isaac;Tagliaferri, Mary;Speed, Terence P.
Estrogenic effects are mediated through two estrogen receptor (ER) subtypes, ERα and ERβ. Estrogens are the most commonly prescribed drugs to treat menopausal conditions, but by non-selectively triggering both ERα and ERβ pathways in different tissues they can cause serious adverse effects. The different sizes of the binding pockets and sequences of their activation function domains indicate that ERα and ERβ should have different specificities for ligands and biological responses that can be exploited for designing safer and more selective estrogens. ERα and ERβ regulate different genes by binding to different regulatory elements and recruiting different transcription and chromatin remodeling factors that are expressed in a cell-specific manner. ERα- and ERβ-selective agonists have been identified that demonstrate that the two ERs produce distinct biological effects. ERα and ERβ agonists are promising new approach for treating specific conditions associated with menopause.
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影响因子：
4.5
作者：
Lin CY;Vega VB;Thomsen JS;Zhang T;Kong SL;Xie M;Chiu KP;Lipovich L;Barnett DH;Stossi F;Yeo A;George J;Kuznetsov VA;Lee YK;Charn TH;Palanisamy N;Miller LD;Cheung E;Katzenellenbogen BS;Ruan Y;Bourque G;Wei CL;Liu ET
通讯作者：
Liu ET
影响因子：
37.8
作者：
Lin J;Steenbergen C;Murphy E;Sun J
通讯作者：
Sun J
影响因子：
30.8
作者：
Carroll, Jason S.;Meyer, Clifford A.;Brown, Myles
通讯作者：
Brown, Myles
影响因子：
4.8
作者：
Hall, JM;McDonnell, DP
通讯作者：
McDonnell, DP
影响因子：
--
作者：
Krum, Susan A.;Miranda-Carboni, Gustavo A.;Brown, Myles
通讯作者：
Brown, Myles