Inhibitory hippocampus-medial septum projection controls locomotion and exploratory behavior.
Inhibitory hippocampus-medial septum projection controls locomotion and exploratory behavior.
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DOI：
10.3389/fnsyn.2023.1042858
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发表时间：
2023
影响因子：
3.7
通讯作者：
Xu, Wei
中科院分区：
文献类型：
--
作者：
Chen, Yuh-Tarng;Arano, Rachel;Guo, Jun;Saleem, Uzair;Li, Ying;Xu, Wei
Although the hippocampus is generally considered a cognitive center for spatial representation, learning, and memory, increasing evidence supports its roles in regulating locomotion. However, the neuronal mechanisms of the hippocampal regulation of locomotion and exploratory behavior remain unclear. In this study, we found that the inhibitory hippocampal synaptic projection to the medial septum (MS) bi-directionally controls the locomotor speed of mice. The activation of the MS-projecting interneurons in the hippocampus or the activation of the hippocampus-originated inhibitory synaptic terminals in the MS decreased locomotion and exploratory behavior. On the other hand, the inhibition of the hippocampus-originated inhibitory synaptic terminals in the MS increased locomotion. Unlike the septal projecting interneurons, the activation of the hippocampal interneurons projecting to the retrosplenial cortex did not change animal locomotion. Therefore, this study reveals a specific long-range inhibitory synaptic output from the hippocampus to the medial septum in the regulation of animal locomotion.
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影响因子：
5.3
作者：
Huh, Carey Y. L.;Goutagny, Romain;Williams, Sylvain
通讯作者：
Williams, Sylvain
影响因子：
16.6
作者：
Bender F;Gorbati M;Cadavieco MC;Denisova N;Gao X;Holman C;Korotkova T;Ponomarenko A
通讯作者：
Ponomarenko A
DOI：
10.1017/s146114570700822x
发表时间：
2008-06-01
影响因子：
4.8
作者：
Degoulet, Mickael;Rouillon, Christophe;Abraini, Jacques H.
通讯作者：
Abraini, Jacques H.
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影响因子：
5.3
作者：
Bian, Xin-Lan;Qin, Cheng;Zhu, Dong-Ya
通讯作者：
Zhu, Dong-Ya
影响因子：
64.5
作者：
Goshen, Inbal;Brodsky, Matthew;Deisseroth, Karl
通讯作者：
Deisseroth, Karl