Remodeling the integration of lipid metabolism between liver and adipose tissue by dietary methionine restriction in rats.
Remodeling the integration of lipid metabolism between liver and adipose tissue by dietary methionine restriction in rats.
复制标题
作者：
Hasek BE;Boudreau A;Shin J;Feng D;Hulver M;Van NT;Laque A;Stewart LK;Stone KP;Wanders D;Ghosh S;Pessin JE;Gettys TW
饮食蛋氨酸限制（MR）产生一系列综合的生化和生理反应，改善代谢健康的生物标志物，限制脂肪增生，提高胰岛素敏感性。使用转录分析，以指导组织特异性评价分子反应MR，我们报告说，肝脏和脂肪组织的转录程序，重塑脂质代谢在每个组织的主要目标。MR饮食产生了肝脏中脂肪生成基因的协调下调，导致肝脏合成和输出脂质的能力相应降低。相反，在白色脂肪组织（WAT）的转录反应涉及一个仓库特异性诱导脂肪生成和氧化基因和相应的能力增加，合成和氧化脂肪酸。这些反应伴随着脂肪细胞形态的显著变化，MR饮食降低了所有贮库中的细胞大小并增加了线粒体密度。通过饮食MR协调肝脏和WAT之间的脂质代谢的转录重塑产生了循环和组织脂质的总体减少，并为饮食产生的代谢灵活性增加和胰岛素敏感性增强提供了潜在的机制。
Dietary methionine restriction (MR) produces an integrated series of biochemical and physiological responses that improve biomarkers of metabolic health, limit fat accretion, and enhance insulin sensitivity. Using transcriptional profiling to guide tissue-specific evaluations of molecular responses to MR, we report that liver and adipose tissue are the primary targets of a transcriptional program that remodeled lipid metabolism in each tissue. The MR diet produced a coordinated downregulation of lipogenic genes in the liver, resulting in a corresponding reduction in the capacity of the liver to synthesize and export lipid. In contrast, the transcriptional response in white adipose tissue (WAT) involved a depot-specific induction of lipogenic and oxidative genes and a commensurate increase in capacity to synthesize and oxidize fatty acids. These responses were accompanied by a significant change in adipocyte morphology, with the MR diet reducing cell size and increasing mitochondrial density across all depots. The coordinated transcriptional remodeling of lipid metabolism between liver and WAT by dietary MR produced an overall reduction in circulating and tissue lipids and provides a potential mechanism for the increase in metabolic flexibility and enhanced insulin sensitivity produced by the diet.
登录
查看更多内容
影响因子：
29
作者：
Hulver, MW;Berggren, JR;Muoio, DM
通讯作者：
Muoio, DM
影响因子：
--
作者：
Cheng, Ying;Zhang, Qian;Guo, Feifan
通讯作者：
Guo, Feifan
影响因子：
8.2
作者：
Kaaman, M.;Sparks, L. M.;Arner, P.
通讯作者：
Arner, P.
DOI：
10.1038/oby.2005.61
发表时间：
2005-03-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Heilbronn, LK;Civitarese, AE;Ravussin, E
通讯作者：
Ravussin, E
影响因子：
29
作者：
Guo, Feifan;Cavener, Douglas R.
通讯作者：
Cavener, Douglas R.