Heterochromatin and gene positioning: inside, outside, any side?
Heterochromatin and gene positioning: inside, outside, any side?
复制标题
DOI：
10.1007/s00412-012-0389-2
复制
发表时间：
2012-12
期刊：
影响因子：
1.6
通讯作者：
Cardoso MC
中科院分区：
文献类型：
--
作者：
Jost KL;Bertulat B;Cardoso MC
所有的细胞过程都依赖于在正确的时间表达和抑制正确的基因。由于每个细胞含有相同的DNA，转录和表观遗传因素必须保持对基因表达的严格控制。即使与正确的转录程序稍有不同，也可能导致严重的缺陷甚至死亡。在破译了完整的线性遗传信息之后，我们需要澄清这些信息是如何组织到真核细胞核的动态和高度异质的三维空间中的。对DNA的高阶组织到不同的缩合水平的观察可以追溯到20世纪初，这些结构特征对基因表达的潜在影响在不久之后就被假设了。特别是，基因与异染色质凝集区的接近对其表达产生了负面影响，因此，异染色质作为亚核沉默间隔的概念应运而生。方法学的进步推动了最近的一系列研究，这些研究只是在一定程度上支持了这一概念。在这篇综述中，我们讨论了(异源)染色质结构和邻近程度如何影响基因表达，并讨论了解决这一基本生物学问题的挑战和方法。
All cellular processes depend on the expression and repression of the right sets of genes at the right time. As each cell contains the same DNA, transcriptional and epigenetic factors have to maintain tight control over gene expression. Even a small divergence from the correct transcriptional program can lead to severe defects and even death. Having deciphered the complete linear genetic information, we need to clarify how this information is organized into the dynamic and highly heterogeneous three-dimensional space of the eukaryotic cell nucleus. Observations on the higher order organization of DNA into differentiated condensation levels date back to the early twentieth century, and potential implications of these structural features to gene expression were postulated shortly after. In particular, proximity of genes to condensed regions of heterochromatin was proposed to negatively influence their expression and, henceforward, the concept of heterochromatin as subnuclear silencing compartment emerged. Methodological advances fueled a flurry of recent studies, which only, in part, led support to this concept. In this review, we address how (hetero)chromatin structure and proximity might influence gene expression and discuss the challenges and means to unravel this fundamental biological question.
登录
查看更多内容
影响因子：
64.5
作者：
HORN, D;CROSS, GAM
通讯作者：
CROSS, GAM
影响因子：
64.8
作者：
Guelen, Lars;Pagie, Ludo;van Steensel, Bas
通讯作者：
van Steensel, Bas
影响因子：
15.3
作者：
Delaire, S;Huang, YH;Robey, EA
通讯作者：
Robey, EA
DOI：
10.1083/jcb.200706060
发表时间：
2008-01-14
期刊：
The Journal of cell biology
影响因子：
--
作者：
Kumaran RI;Spector DL
通讯作者：
Spector DL
影响因子：
64.5
作者：
Filion GJ;van Bemmel JG;Braunschweig U;Talhout W;Kind J;Ward LD;Brugman W;de Castro IJ;Kerkhoven RM;Bussemaker HJ;van Steensel B
通讯作者：
van Steensel B