Biophysics Role and Biomimetic Culture Systems of ECM Stiffness in Cancer EMT.
Biophysics Role and Biomimetic Culture Systems of ECM Stiffness in Cancer EMT.
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DOI：
10.1002/gch2.202100094
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发表时间：
2022-06
影响因子：
4.9
通讯作者：
Ruan, Jing
中科院分区：
文献类型：
--
作者：
Tian, Hao;Shi, Hanhan;Yu, Jie;Ge, Shengfang;Ruan, Jing
关键词：
肿瘤疾病已成为全球第二大非传染性疾病死亡原因，对人类健康构成重大威胁。随着癌症研究的不断进展，人们发现肿瘤微环境（TME）的机械线索在许多癌症的进展中发挥着不可替代的作用。作为主要的细胞外机械信号载体，细胞外基质（ECM）硬度可能通过生物力学转导改变下游基因表达、促进上皮间质转化（EMT）并调节癌细胞的干性来影响癌症进展。 EMT是诱导癌细胞转移的重要机制，并且受到ECM硬度的密切影响，无论是独立的还是与其他分子共同作用的。在这篇综述中，首先总结了 ECM 硬度在不同类型癌症的 EMT 中的独特作用。通过不断研究 ECM 硬度在癌症进展中的重要性，开发了一种基于 3D 制造和新型材料技术的仿生培养系统来模拟 ECM 硬度。然后，作者回顾了 ECM 硬度仿生培养系统的新发展，最后提供了关于 ECM 硬度在癌症进展中的新见解，这可以拓宽该领域的视野，以开发新的癌症诊断方法和疗法。细胞外基质（ECM）硬化不仅是疾病的结果，也是疾病发展的一个促成因素。 ECM硬度可以独立启动上皮间质转化（EMT）或在肿瘤细胞EMT过程中充当共刺激或“催化剂”。同时，新型ECM刚度仿生培养系统为ECM的生物物理研究提供了更合适的选择。
Oncological diseases have become the second leading cause of death from noncommunicable diseases worldwide and a major threat to human health. With the continuous progress in cancer research, the mechanical cues from the tumor microenvironment environment (TME) have been found to play an irreplaceable role in the progression of many cancers. As the main extracellular mechanical signal carrier, extracellular matrix (ECM) stiffness may influence cancer progression through biomechanical transduction to modify downstream gene expression, promote epithelial‐mesenchymal transition (EMT), and regulate the stemness of cancer cells. EMT is an important mechanism that induces cancer cell metastasis and is closely influenced by ECM stiffness, either independently or in conjunction with other molecules. In this review, the unique role of ECM stiffness in EMT in different kinds of cancers is first summarized. By continually examining the significance of ECM stiffness in cancer progression, a biomimetic culture system based on 3D manufacturing and novel material technologies is developed to mimic ECM stiffness. The authors then look back on the novel development of the ECM stiffness biomimetic culture systems and finally provide new insights into ECM stiffness in cancer progression which can broaden the fields’ horizons with a view toward developing new cancer diagnosis methods and therapies. Extracellular matrix (ECM) stiffening is not only a disease consequence but also a contributing factor to disease development. ECM stiffness can independently initiate epithelial‐mesenchymal transition (EMT) or act as a costimulatory or “catalyst” in the tumor cell EMT process. Meanwhile, novel ECM stiffness biomimetic culture systems provide more suitable choices for the biophysical study of ECM.
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影响因子：
16.6
作者：
Chaudhuri O;Gu L;Darnell M;Klumpers D;Bencherif SA;Weaver JC;Huebsch N;Mooney DJ
通讯作者：
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影响因子：
64.8
作者：
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通讯作者：
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DOI：
10.1016/j.jmbbm.2011.08.016
发表时间：
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影响因子：
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作者：
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通讯作者：
Ottenio, Melanie
DOI：
10.1016/j.bbamcr.2019.118526
发表时间：
2019-12-01
影响因子：
5.1
作者：
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通讯作者：
Warkiani, Majid Ebrahimi
影响因子：
4.8
作者：
Amano, M;Ito, M;Kaibuchi, K
通讯作者：
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