Closing the gap: increases in life expectancy among treated HIV-positive individuals in the United States and Canada.
Closing the gap: increases in life expectancy among treated HIV-positive individuals in the United States and Canada.
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DOI：
10.1371/journal.pone.0081355
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of IeDEA
中科院分区：
文献类型：
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作者：
Samji H;Cescon A;Hogg RS;Modur SP;Althoff KN;Buchacz K;Burchell AN;Cohen M;Gebo KA;Gill MJ;Justice A;Kirk G;Klein MB;Korthuis PT;Martin J;Napravnik S;Rourke SB;Sterling TR;Silverberg MJ;Deeks S;Jacobson LP;Bosch RJ;Kitahata MM;Goedert JJ;Moore R;Gange SJ;North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of IeDEA
联合抗逆转录病毒疗法（ART）显着提高了美国艾滋病毒阳性成人的生存率（美国）和加拿大，但该地区预期寿命的增长并没有得到很好的描述。我们的目标是估计2000-2007年美国和加拿大接受抗逆转录病毒治疗的艾滋病毒阳性成年人预期寿命的时间变化。参与者来自北美艾滋病队列研究与设计合作组织（NA-ACCORD），年龄≥20岁，接受ART治疗。死亡率使用参与者从2000年1月1日或ART开始至死亡、失访或2007年12月31日行政删失的人时计算。20岁时的预期寿命是使用简略寿命表估算的，其定义是，如果目前按年龄划分的死亡率保持不变，某一特定年龄的人还能活的平均年数。粗死亡率为19.8/1 000人-年，22 937人中有82 022人-年和1 622人死亡。从2000-2002年到2006-2007年，预期寿命从36.1岁[标准误0.5]增加到51.4岁[标准误0.5]。除最后一个时期（2006-2007年）外，男子和妇女在所有时期的预期寿命都相当。有注射吸毒史的个体、非白人和基线CD 4计数<350个细胞/mm 3的患者的预期寿命较低。在美国或加拿大，一个20岁的艾滋病毒阳性成年人接受抗逆转录病毒治疗，预计将活到70岁出头，预期寿命接近一般人群。性别、种族、艾滋病毒传播风险组和CD 4计数的差异仍然存在。
Combination antiretroviral therapy (ART) has significantly increased survival among HIV-positive adults in the United States (U.S.) and Canada, but gains in life expectancy for this region have not been well characterized. We aim to estimate temporal changes in life expectancy among HIV-positive adults on ART from 2000–2007 in the U.S. and Canada. Participants were from the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD), aged ≥20 years and on ART. Mortality rates were calculated using participants' person-time from January 1, 2000 or ART initiation until death, loss to follow-up, or administrative censoring December 31, 2007. Life expectancy at age 20, defined as the average number of additional years that a person of a specific age will live, provided the current age-specific mortality rates remain constant, was estimated using abridged life tables. The crude mortality rate was 19.8/1,000 person-years, among 22,937 individuals contributing 82,022 person-years and 1,622 deaths. Life expectancy increased from 36.1 [standard error (SE) 0.5] to 51.4 [SE 0.5] years from 2000–2002 to 2006–2007. Men and women had comparable life expectancies in all periods except the last (2006–2007). Life expectancy was lower for individuals with a history of injection drug use, non-whites, and in patients with baseline CD4 counts <350 cells/mm3. A 20-year-old HIV-positive adult on ART in the U.S. or Canada is expected to live into their early 70 s, a life expectancy approaching that of the general population. Differences by sex, race, HIV transmission risk group, and CD4 count remain.
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影响因子：
168.9
作者：
Montaner, Julio S. G.;Lima, Viviane D.;Barrios, Rolando;Yip, Benita;Wood, Evan;Kerr, Thomas;Shannon, Kate;Harrigan, P. Richard;Hogg, Robert S.;Daly, Patricia;Kendall, Peny
通讯作者：
Kendall, Peny
DOI：
10.1016/s0140-6736(08)61113-7
发表时间：
2008-07-26
期刊：
Lancet (London, England)
影响因子：
--
作者：
Antiretroviral Therapy Cohort Collaboration
通讯作者：
Antiretroviral Therapy Cohort Collaboration
影响因子：
11.8
作者：
Losina, Elena;Schackman, Bruce R.;Freedberg, Kenneth A.
通讯作者：
Freedberg, Kenneth A.
影响因子：
4.6
作者：
Justice, Amy C
通讯作者：
Justice, Amy C
影响因子：
3.8
作者：
Lloyd-Smith, E;Brodkin, E;Hogg, RS
通讯作者：
Hogg, RS