Distributed and retinotopically asymmetric processing of coherent motion in mouse visual cortex

Distributed and retinotopically asymmetric processing of coherent motion in mouse visual cortex
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小鼠视觉皮层相干运动的分布式和视网膜局部不对称处理

DOI:
10.1038/s41467-020-17283-5
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发表时间:
2020
影响因子:
16.6
通讯作者:
Goard, Michael J.
Goard, Michael J.
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Sit, Kevin K.;Goard, Michael J.

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视觉运动的感知对于哺乳动物的一系列行为学行为很重要。在灵长类动物中,特定的视觉皮层区域专门用于处理连贯的视觉运动。然而,尽管强大的遗传工具可用于测量群体神经活动,但小鼠视觉皮层是否具有类似的组织仍不清楚。在这里,我们使用转基因小鼠的宽场和 2 光子钙成像来测量对相干运动的介观和细胞反应。在呈现自然电影和随机点运动图 (RDK) 期间,初级视觉皮层 (V1) 和高级视觉区域 (HVA) 的成像揭示了对连贯运动的不同响应,与腹侧流区域相比,背侧流区域的响应更强。此外,视觉区域内存在相当大的各向异性,使得代表较低视野的神经元对相干运动更敏感。这些结果表明,小鼠皮层视觉运动的处理在视觉区域之间和视觉区域内分布不均匀。
Perception of visual motion is important for a range of ethological behaviors in mammals. In primates, specific visual cortical regions are specialized for processing of coherent visual motion. However, whether mouse visual cortex has a similar organization remains unclear, despite powerful genetic tools available for measuring population neural activity. Here, we use widefield and 2-photon calcium imaging of transgenic mice to measure mesoscale and cellular responses to coherent motion. Imaging of primary visual cortex (V1) and higher visual areas (HVAs) during presentation of natural movies and random dot kinematograms (RDKs) reveals varied responsiveness to coherent motion, with stronger responses in dorsal stream areas compared to ventral stream areas. Moreover, there is considerable anisotropy within visual areas, such that neurons representing the lower visual field are more responsive to coherent motion. These results indicate that processing of visual motion in mouse cortex is distributed heterogeneously both across and within visual areas.
DOI: 10.1101/sqb.1990.055.01.065
发表时间: 1990
期刊: Cold Spring Harbor symposia on quantitative biology
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发表时间: 1983-01-01
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影响因子: 64.8
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