Comprehensive classification of nucleotidyltransferase fold proteins: identification of novel families and their representatives in human.
Comprehensive classification of nucleotidyltransferase fold proteins: identification of novel families and their representatives in human.
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DOI：
10.1093/nar/gkp854
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发表时间：
2009-12
影响因子：
14.9
通讯作者：
Ginalski K
中科院分区：
文献类型：
--
作者：
Kuchta K;Knizewski L;Wyrwicz LS;Rychlewski L;Ginalski K
本文综述了核苷酰转移酶折叠蛋白超家族的进化历史、序列结构多样性和所发挥的功能。利用顶级同源性检测方法，结合传递搜索和折叠识别，我们在众多已编目的蛋白质家族和结构数据库中修正了这些超家族的结构域，并鉴定了10个新的核苷酸转移酶折叠家族。这些家族包括数百个以前未被鉴定的和各种注释不佳的蛋白质，如Fukutin/LICD、NFAT、FAM46、Mab-21和NRAP。其中一些蛋白质似乎扮演着以前没有在这个超家族中观察到的新的重要作用，例如调节基因表达或将胆碱掺入细胞膜。重要的是，在新检测到的家族中，我们在人类基因组中发现了25个新的超家族成员。在这些新分配的成员中，有一些已知与先天性肌营养不良、神经疾病和视网膜色素变性有关的蛋白质，这为这些遗传疾病的分子背景提供了一些新的线索。12个新的人类核苷酸转移酶折叠蛋白属于已知参与器官发生和发育的Mab-21家族。确定这些新检测到的蛋白质的特定生物学功能仍然是一项具有挑战性的任务。
This article presents a comprehensive review of large and highly diverse superfamily of nucleotidyltransferase fold proteins by providing a global picture about their evolutionary history, sequence-structure diversity and fulfilled functional roles. Using top-of-the-line homology detection method combined with transitive searches and fold recognition, we revised the realm of these superfamily in numerous databases of catalogued protein families and structures, and identified 10 new families of nucleotidyltransferase fold. These families include hundreds of previously uncharacterized and various poorly annotated proteins such as Fukutin/LICD, NFAT, FAM46, Mab-21 and NRAP. Some of these proteins seem to play novel important roles, not observed before for this superfamily, such as regulation of gene expression or choline incorporation into cell membrane. Importantly, within newly detected families we identified 25 novel superfamily members in human genome. Among these newly assigned members are proteins known to be involved in congenital muscular dystrophy, neurological diseases and retinal pigmentosa what sheds some new light on the molecular background of these genetic disorders. Twelve of new human nucleotidyltransferase fold proteins belong to Mab-21 family known to be involved in organogenesis and development. The determination of specific biological functions of these newly detected proteins remains a challenging task.
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影响因子：
14.9
作者：
Jensen LJ;Kuhn M;Stark M;Chaffron S;Creevey C;Muller J;Doerks T;Julien P;Roth A;Simonovic M;Bork P;von Mering C
通讯作者：
von Mering C
影响因子：
11.4
作者：
Isken, O;Grassmann, CW;Behrens, SE
通讯作者：
Behrens, SE
影响因子：
16.8
作者：
Garcia-Diaz, M;Bebenek, K;Pedersen, LC
通讯作者：
Pedersen, LC
影响因子：
14.9
作者：
Ginalski, K;von Grotthuss, M;Rychlewski, L
通讯作者：
Rychlewski, L
影响因子：
9.8
作者：
Brockington, M;Blake, DJ;Muntoni, F
通讯作者：
Muntoni, F