Identification of early interstitial lung disease in smokers from the COPDGene Study.
Identification of early interstitial lung disease in smokers from the COPDGene Study.
复制标题
DOI：
10.1016/j.acra.2009.07.016
复制
发表时间：
2010-01
影响因子：
4.8
通讯作者：
Hatabu, Hiroto
中科院分区：
文献类型：
--
作者：
Washko, George R.;Lynch, David A.;Matsuoka, Shin;Ross, James C.;Umeoka, Shigeaki;Diaz, Alejandro;Sciurba, Frank C.;Hunninghake, Gary M.;Estepar, Raul San Jose;Silverman, Edwin K.;Rosas, Ivan O.;Hatabu, Hiroto
比较两种主观方法用于识别胸部计算机断层扫描（CT）提示早期间质性肺病（ILD）的变化。使用顺序阅读器和组共识解释方案检查来自单个机构的COPDGene研究中招募的前100名受试者的CT扫描。使用评分系统“0”或正常，“1”或不确定是否存在ILD，“2”高度可疑ILD，“3”典型ILD变化，评价CT是否存在与ILD一致的实质变化。对早期ILD病例与正常受试者进行统计学比较。两种方法之间的一致性较高（Kappa 0.84 95%CI（0.73-0.94）P <0.0001，序贯法和共识法）。序贯阅读方法预测一致阅片的阳性和阴性值均较高（0.97），尽管胸部CT评价次数减少了58%。无论解释方法如何，在COPD基因的吸烟者亚组中，胸部CT改变与早期ILD一致的患病率在5- 10%之间变化。患有早期ILD的受试者往往比没有早期ILD的受试者有更大的烟草烟雾暴露（P=0.053）。顺序CT解释方案是CT数据直观解释的有效方法。需要进一步的研究来独立证实我们的发现，并进一步描述吸烟者的早期ILD。
To compare two subjective methods for the identification of changes suggestive of early interstitial lung disease (ILD) on chest computed tomographic (CT) scan. The CT scans of the first 100 subjects enrolled in the COPDGene Study from a single institution were examined using a sequential reader and a group consensus interpretation scheme. CTs were evaluated for the presence of parenchymal changes consistent with ILD using a scoring system of “0” or normal, “1” or equivocal for the presence of ILD, “2” highly suspicious for ILD, “3” classic ILD changes. A statistical comparison of early ILD cases with normal subjects was performed. There was a high degree of agreement between methods (Kappa 0.84 95% CI (0.73–0.94) P <0.0001 for the sequential and consensus methods). The sequential reading method had both high positive and negative values (0.97) for predicting a consensus read despite a 58% reduction in the number of chest CT evaluations. Regardless of interpretation method, the prevalence of chest CT changes consistent with early ILD in this subset of smokers from COPDGene varies between 5–10%. Subjects with early ILD tended to have greater tobacco smoke exposure than subjects without early ILD (P=0.053). A sequential CT interpretation scheme is efficient method for the visual interpretation of CT data. Further investigation is required to independently confirm our findings and further characterize early ILD in smokers.
登录
查看更多内容
DOI：
10.1164/rccm.200602-163oc
发表时间：
2006-10-01
影响因子：
24.7
作者：
Raghu, Ganesh;Weycker, Derek;Oster, Gerry
通讯作者：
Oster, Gerry
DOI：
10.1093/jee/39.2.269
发表时间：
1945-01-01
期刊：
BIOMETRICS BULLETIN
影响因子：
--
作者：
WILCOXON, F
通讯作者：
WILCOXON, F
影响因子：
5.5
作者：
Attili, Anil K.;Kazerooni, Ella A.;Martinez, Fernando J.
通讯作者：
Martinez, Fernando J.
影响因子：
158.5
作者：
BITTERMAN, PB;RENNARD, SI;CRYSTAL, RG
通讯作者：
CRYSTAL, RG
影响因子：
10
作者：
Hodgson, U;Laitinen, T;Tukiainen, P
通讯作者：
Tukiainen, P