Spatial learning depends on both the addition and removal of new hippocampal neurons.
Spatial learning depends on both the addition and removal of new hippocampal neurons.
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DOI：
10.1371/journal.pbio.0050214
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发表时间：
2007-08
期刊：
影响因子：
9.8
通讯作者：
Abrous DN
中科院分区：
文献类型：
--
作者：
Dupret D;Fabre A;Döbrössy MD;Panatier A;Rodríguez JJ;Lamarque S;Lemaire V;Oliet SH;Piazza PV;Abrous DN
成年海马区神经发生在空间学习中的作用仍然存在争议。在这里，我们表明，空间学习通过诱导一系列类似于表征发育的选择性稳定过程的事件来改变神经发生。学习促进相对成熟的神经元存活，促进更多不成熟细胞的凋亡，最后促进神经前体的增殖。这是调节学习的三个相互关联的事件。因此，阻止细胞凋亡会损害记忆，抑制学习诱导的细胞存活和细胞增殖。总而言之，在学习过程中，与选择性稳定过程类似，神经元网络是通过严格控制对不同新生神经元群体的选择和抑制而形成的。成年海马神经元的诞生与学习和记忆能力的增强有关。特别是，空间学习增加了新生细胞的存活和增殖，但令人惊讶的是，它也减少了它们的数量。在这里，我们假设空间学习也依赖于新生海马神经元的死亡。我们研究了在水迷宫中的空间学习对啮齿动物海马区细胞出生和死亡的影响。然后，我们确定了一种细胞死亡抑制剂对记忆能力的影响，以及学习诱导的细胞死亡、细胞增殖和细胞存活的变化。我们发现，在特定的发育阶段，学习会增加对最年轻新生细胞的清除。细胞死亡抑制剂损害记忆能力，阻断学习诱导的细胞死亡、学习对新生的老年神经元的存活促进作用，以及随后学习诱导的神经前体细胞增殖。这些结果表明，空间学习导致海马区细胞死亡，这是一种从属于学习的现象，对于新生的老年神经元的生存和神经前体的增殖都是必要的。这些发现表明，在学习过程中，神经元网络是由严格调控的新生神经元选择形成的，并揭示了一种新的机制，调节成人大脑的学习和记忆。空间学习诱导的海马区细胞死亡对于新生细胞的存活、神经前体细胞的增殖和空间记忆的保持是必要的。
The role of adult hippocampal neurogenesis in spatial learning remains a matter of debate. Here, we show that spatial learning modifies neurogenesis by inducing a cascade of events that resembles the selective stabilization process characterizing development. Learning promotes survival of relatively mature neurons, apoptosis of more immature cells, and finally, proliferation of neural precursors. These are three interrelated events mediating learning. Thus, blocking apoptosis impairs memory and inhibits learning-induced cell survival and cell proliferation. In conclusion, during learning, similar to the selective stabilization process, neuronal networks are sculpted by a tightly regulated selection and suppression of different populations of newly born neurons. The birth of adult hippocampal neurons is associated with enhanced learning and memory performance. In particular, spatial learning increases the survival and the proliferation of newborn cells, but surprisingly, it also decreases their number. Here, we hypothesized that spatial learning also depends upon the death of newborn hippocampal neurons. We examined the effect of spatial learning in the water maze on cell birth and death in the rodent hippocampus. We then determined the influence of an inhibitor of cell death on memory abilities and learning-induced changes in cell death, cell proliferation, and cell survival. We show that learning increases the elimination of the youngest newborn cells during a specific developmental period. The cell-death inhibitor impairs memory abilities and blocks the learning-induced cell death, the survival-promoting effect of learning on older newly born neurons, and the subsequent learning-induced proliferation of neural precursors. These results show that spatial learning induces cell death in the hippocampus, a phenomenon that subserves learning and is necessary for both the survival of older newly born neurons and the proliferation of neural precursors. These findings suggest that during learning, neuronal networks are sculpted by a tightly regulated selection of newly born neurons and reveal a novel mechanism mediating learning and memory in the adult brain. Spatial learning-induced cell death in the hippocampus is necessary for the survival of newly born cells, the proliferation of neural precursors, and the retention of spatial memories.
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影响因子：
2.5
作者：
Ehninger, D;Kempermann, G
通讯作者：
Kempermann, G
影响因子：
2.5
作者：
Dayer, AG;Ford, AA;Cameron, HA
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Cameron, HA
影响因子：
7.8
作者：
Bauer, S;Patterson, PH
通讯作者：
Patterson, PH
影响因子：
16.2
作者：
CASTILLO, PE;WEISSKOPF, MG;NICOLL, RA
通讯作者：
NICOLL, RA
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1.7
作者：
Dash, PK;Blum, S;Moore, AN
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Moore, AN