Nitroglycerin-induced coronary vasodilation is not enhanced in patients with impaired endothelium-dependent dilation.
Nitroglycerin-induced coronary vasodilation is not enhanced in patients with impaired endothelium-dependent dilation.
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在内皮依赖性扩张受损的患者中，硝酸甘油诱导的冠状血管扩张不会增强。
DOI：
10.1016/0735-1097(96)00221-5
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发表时间：
1996
影响因子：
24
通讯作者：
Ganz,P
中科院分区：
文献类型：
--
作者：
Anderson,TJ;Meredith,IT;Charbonneau,F;Yeung,AC;Dyce,M;Selwyn,AP;Ganz,P
ObjectivesThis study was designed to determine whether enhanced sensitivity to exogenous nitrovasodilators is present in the coronary arteries of patients with impaired endothelium-dependent dilation.BackgroundAnimal studies have demonstrated that the dilator response to exogenous nitrovasodilators is exaggerated in the setting of endothelial dysfunction (diminished nitric oxide activity). Whether such relative hyperresponsiveness to exogenous nitrates occurs and is important in humans is unknown.MethodsWe assessed coronary vasomotion in 110 patients (mean [±SD] age 56 ± 10 years) by serial intracoronary infusions of acetylcholine (10−8to 10−6mol/liter) to test endogenous nitric oxide and nitroglycerin (40 μg) to test responses to exogenous nitrovasodilators.ResultsThe vasomotor response to 10−6mol/liter of acetylcholine differed between patients with (n = 95) and those without (n = 15) normal endothelial dysfunction (−21 ± 14% vs. 12 ± 8% respectively, p < 0.001). However, neither the dilator response to nitroglycerin (21 ± 14% vs. 18 ± 13%) nor the baseline diameter differed between those with endothelial dysfunction and normal function, respectively. There was no correlation between the magnitude of the dilator response to nitroglycerin and acetylcholine. The response to nitroglycerin was decreased with increasing age (r = −0.21, p = 0.03) but was not related to any other demographic factors or to the angiographic appearance of the vessel.ConclusionsThe coronary vasodilator response to nitroglycerin is not significantly enhanced in patients with impaired endothelium-dependent dilation but decreases with increasing age. This finding provides indirect evidence that basal coronary tone is not increased in patients with endothelial dysfunction and that supersensitivity to exogenous nitrates is not clinically important in humans.
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DOI：
--
发表时间：
1981-09
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
L. Ignarro;H. Lippton;J. Edwards;W. Baricos;A. Hyman;P. Kadowitz;C. A. Gruetter
通讯作者：
L. Ignarro;H. Lippton;J. Edwards;W. Baricos;A. Hyman;P. Kadowitz;C. A. Gruetter
影响因子：
158.5
作者：
LUDMER, PL;SELWYN, AP;GANZ, P
通讯作者：
GANZ, P
人类的大冠状动脉对血流变化有反应：这是一种内皮依赖性机制，在动脉粥样硬化患者中失效。
影响因子：
24
作者：
Nabel,EG;Selwyn,AP;Ganz,P
通讯作者：
Ganz,P
内皮去除增强硝普钠和亚硝酸钠的血管舒张作用。
影响因子：
5
作者：
YasufumiShirasaki;Che Su
通讯作者：
Che Su
内皮源性松弛因子抑制硝基化合物在离体动脉中的作用。
DOI：
10.1152/ajpheart.1987.252.2.h307
发表时间：
1987
期刊：
The American journal of physiology
影响因子：
--
作者：
U. Pohl;R. Busse
通讯作者：
R. Busse