A Novel Post-Operative ALRI Model Accurately Predicts Clinical Outcomes of Resected Hepatocellular Carcinoma Patients.
A Novel Post-Operative ALRI Model Accurately Predicts Clinical Outcomes of Resected Hepatocellular Carcinoma Patients.
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新型术后 ALRI 模型可准确预测肝细胞癌切除患者的临床结果
DOI：
10.3389/fonc.2021.665497
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发表时间：
2021
影响因子：
4.7
通讯作者：
Zhou Y
中科院分区：
文献类型：
--
作者：
Liao M;Sun J;Zhang Q;Tang C;Zhou Y;Cao M;Chen T;Hu C;Yu J;Song Y;Li M;Liao W;Zhou Y
背景肝细胞癌（Hepatocellular carcinoma，HCC）是世界范围内最常见的恶性肿瘤之一。肝癌的预后和长期生存率仍然不令人满意，即使在根治性切除术后，许多非侵入性预测因素已被探索为术后患者。大多数预后预测模型是基于术前的临床特征和病理结果。本研究的目的是探讨一个新构建的诺模图，其中包括术后天冬氨酸转氨酶淋巴细胞比率指数（ALRI）的预后价值。方法选取3个医学中心771例肝癌根治术患者，分为培训组（n = 416）和验证组（n = 355）。采用受试者工作曲线（ROC）分析评估ALRI的预后预测潜力。考克斯回归模型用于确定独立的预后因素。构建了总生存期（OS）和无病生存期（DFS）的列线图，并在外部进一步验证。结果ROC曲线分析显示ALRI是预测肝癌切除的最有效指标，其临界值为22.6。ALRI水平越高，肿瘤越大，TNM分期越高，而白蛋白水平越低，OS和DFS越短。OS和DFS的列线图能够将HCC患者区分为不同的风险组。结论术后ALRI对肝癌预后有一定的预测价值。这种新的诺模图可以将HCC患者分为不同的风险组，并为术后患者提供个体化监测参考。
Background Hepatocellular carcinoma (HCC) is one of the leading malignant tumors worldwide. Prognosis and long-term survival of HCC remain unsatisfactory, even after radical resection, and many non-invasive predictors have been explored for post-operative patients. Most prognostic prediction models were based on preoperative clinical characteristics and pathological findings. This study aimed to investigate the prognostic value of a newly constructed nomogram, which incorporated post-operative aspartate aminotransferase to lymphocyte ratio index (ALRI). Methods A total of 771 HCC patients underwent radical resection from three medical centers were enrolled and grouped into the training cohort (n = 416) and validation cohort (n = 355). Prognostic prediction potential of ALRI was assessed by receiver operating curve (ROC) analysis. The Cox regression model was used to identify independent prognostic factors. Nomograms for overall survival (OS) and disease-free survival (DFS) were constructed and further validated externally. Results The ROC analysis ranked ALRI as the most effective prediction marker for resected HCC patients, with the cut-off value determined at 22.6. Higher ALRI level positively correlated with larger tumor size, higher tumor node metastasis (TNM) stage, and inversely with lower albumin level and shorter OS and DFS. Nomograms for OS and DFS were capable of discriminating HCC patients into different risk-groups. Conclusions Post-operative ALRI was of prediction value for HCC prognosis. This novel nomogram may categorize HCC patients into different risk groups, and offer individualized surveillance reference for post-operative patients.
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影响因子：
29.4
作者：
El-Serag HB
通讯作者：
El-Serag HB
DOI：
10.1002/hep.29561
发表时间：
2018-03
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Luo P;Yin P;Hua R;Tan Y;Li Z;Qiu G;Yin Z;Xie X;Wang X;Chen W;Zhou L;Wang X;Li Y;Chen H;Gao L;Lu X;Wu T;Wang H;Niu J;Xu G
通讯作者：
Xu G
影响因子：
50.3
作者：
Nakagawa S;Wei L;Song WM;Higashi T;Ghoshal S;Kim RS;Bian CB;Yamada S;Sun X;Venkatesh A;Goossens N;Bain G;Lauwers GY;Koh AP;El-Abtah M;Ahmad NB;Hoshida H;Erstad DJ;Gunasekaran G;Lee Y;Yu ML;Chuang WL;Dai CY;Kobayashi M;Kumada H;Beppu T;Baba H;Mahajan M;Nair VD;Lanuti M;Villanueva A;Sangiovanni A;Iavarone M;Colombo M;Llovet JM;Subramanian A;Tager AM;Friedman SL;Baumert TF;Schwarz ME;Chung RT;Tanabe KK;Zhang B;Fuchs BC;Hoshida Y;Precision Liver Cancer Prevention Consortium
通讯作者：
Precision Liver Cancer Prevention Consortium
影响因子：
3.9
作者：
Zhao, Li-Yun;Yang, Dong-Dong;Wu, Xiang-Yuan
通讯作者：
Wu, Xiang-Yuan
炎症评分对肝切除术后早期复发性肝细胞癌预后价值的比较
影响因子：
6.7
作者：
Wang, Chenwei;He, Wei;Yuan, Yunfei
通讯作者：
Yuan, Yunfei