Epidemiology of viral hepatitis and hepatocellular carcinoma.

Epidemiology of viral hepatitis and hepatocellular carcinoma.
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DOI:
10.1053/j.gastro.2011.12.061
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发表时间:
2012-05
期刊:
影响因子:
29.4
通讯作者:
El-Serag HB
El-Serag HB
中科院分区:
医学1区
文献类型:
--
作者:
El-Serag HB

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大多数肝细胞癌(HCC)病例与慢性B肝炎病毒(HBV)或丙型肝炎病毒(HCV)感染相关的肝硬化有关。HCC的时间趋势的变化以及不同地区之间年龄、性别和种族特异性比率的大多数变化可能与人群中最流行的肝炎病毒的差异、其传播的时间以及病毒感染个体的年龄有关。环境、宿主遗传和病毒因素可影响HBV或HCV感染个体发生HCC的风险。本综述总结了HBV或HCV感染者中HCC的危险因素,基于流行病学研究和荟萃分析的结果,以及全球和美国患者结局和HCC疾病负担的决定因素。
Most cases of hepatocellular carcinoma (HCC) are associated with cirrhosis related to chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection. Changes in the time trends of HCC and most variations in its age-, sex-, and race-specific rates among different regions are likely to be related to differences in hepatitis viruses that are most prevalent in a population, the timing of their spread, and the ages of the individuals the viruses infect. Environmental, host genetic, and viral factors can affect the risk of HCC in individuals with HBV or HCV infection. This review summarizes the risk factors for HCC among HBV- or HCV-infected individuals, based on findings from epidemiological studies and meta-analyses, as well as determinants of patient outcome and the HCC disease burden, globally and in the US.
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