Increased Hypocretin (Orexin) Plasma Level in Depression, Bipolar Disorder Patients.
Increased Hypocretin (Orexin) Plasma Level in Depression, Bipolar Disorder Patients.
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抑郁症、双相情感障碍患者的血浆下丘脑分泌素（食欲素）水平升高
DOI：
10.3389/fpsyt.2021.676336
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发表时间：
2021
影响因子：
4.7
通讯作者：
Xu Y
中科院分区：
文献类型：
--
作者：
Li H;Lu J;Li S;Huang B;Shi G;Mou T;Xu Y
As hypocretin can markedly affect neurophysiological and behavioural processes in mood disorders. However, few studies have measured changes in hypocretin levels in patients with mood disorders. We estimated the hypocretin-1 plasma levels in mood disorder patients and controls (CON) using an enzyme-linked immunosorbent assay. Results: (i) The hypocretin-1 plasma level was significantly higher in major depressive disorder (MDD) patients [59.04 (35.78–80.12) pg/ml, P < 0.001] and bipolar disorder (BD) patients [65.50 (58.46–74.57) pg/ml, P < 0.001] patients than in CON [49.25 (28.51–80.40) pg/ml]. Moreover, the plasma hypocretin-1 levels in the BD group were significantly higher than those in the MDD group (P < 0.001). (ii). In the MDD group, patients with higher suicidal ideation had higher hypocretin-1 levels [62.09 (38.23–80.12) pg/ml] than those with lower suicidal ideation [59.63 (35.79–77.37) pg/ml), P = 0.032]. (iii). Plasma hypocretin-1 levels were increased in both female and male mood disorder patients compared to CON [male: MDD 60.51 (35.79–80.12) pg/ml; BD 65.40 (58.76–74.14) pg/ml; CON 45.63 (28.51–62.05) pg/ml; all P < 0.016; female: MDD 57.37 (34.59–80.40) pg/ml; BD 65.61 (58.46–74.57) pg/ml; CON 52.92 (38.23–78.89) pg/ml; all P < 0.015]. (iv). In CON, we found a significant negative correlation between plasma hypocretin-1 levels and age (rho = −0.251, P = 0.032), while this negative correlation was absent in the MDD and BD groups. Limitations may partly arise from the relatively small sample size and the medication history of patients participating in our research. We concluded that the clear changes found in plasma hypocretin-1 levels might be applied in the diagnosis of depression and the differential diagnosis of MDD and BD. The clear suicidal-ideation-related change found in hypocretin-1 levels in depression might be taken into account in the prevention of suicidal behaviour and further study of hypocretin-targeted therapies.
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影响因子：
3.7
作者：
Arendt, David H.;Hassell, James;Li, Hao;Achua, Justin K.;Guarnieri, Douglas J.;DiLeone, Ralph J.;Ronan, Patrick J.;Summers, Cliff H.
通讯作者：
Summers, Cliff H.
影响因子：
6.6
作者：
Desseilles, Martin;Perroud, Nader;Courtet, Philippe
通讯作者：
Courtet, Philippe
DOI：
10.1212/01.con.0000427212.05930.c4
发表时间：
2013-02-01
期刊：
Continuum (Minneapolis, Minn.)
影响因子：
--
作者：
Malhotra, Samit;Kushida, Clete A
通讯作者：
Kushida, Clete A
影响因子：
7.6
作者：
Nollet, Mathieu;Gaillard, Philippe;Leman, Samuel
通讯作者：
Leman, Samuel
新生儿给予氯米帕明引起的抑郁症大鼠模型中脑甲状腺素水平的变化。
DOI：
10.1177/0269881106082899
发表时间：
2008-09
期刊：
Journal of psychopharmacology (Oxford, England)
影响因子：
--
作者：
Feng P;Vurbic D;Wu Z;Hu Y;Strohl KP
通讯作者：
Strohl KP