Changes in brain orexin levels in a rat model of depression induced by neonatal administration of clomipramine.
Changes in brain orexin levels in a rat model of depression induced by neonatal administration of clomipramine.
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新生儿给予氯米帕明引起的抑郁症大鼠模型中脑甲状腺素水平的变化。
DOI：
10.1177/0269881106082899
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发表时间：
2008-09
期刊：
影响因子：
--
通讯作者：
Strohl KP
中科院分区：
文献类型：
--
作者：
Feng P;Vurbic D;Wu Z;Hu Y;Strohl KP
抑郁症与血清素能神经元的缺乏有关，血清素能神经元被发现会抑制食欲能神经元，而食欲能神经元反过来又会在一个反馈回路中激活这些神经元。这一证据表明食欲素可能与抑郁症的病理有关。从出生后第8 ~ 21天开始用氯丙帕明（CLI）和生理盐水（SAL）治疗Long Evans大鼠。两组各取一组大鼠，于35日龄处死，定量测定多脑区食欲素。在3-4个月大时，第二组大鼠在强迫游泳过程中被测试为不能动，这是大鼠抑郁症状的常见测试，第三组被处死用于定量食欲素。与对照大鼠相比，新生期CLI治疗的成年大鼠(1)强迫游泳不动增加，(2)下丘脑食欲素A和B增加。然而，与同龄对照组相比，幼年CLI大鼠的多个脑区食欲素A和B水平均下降。我们得出结论，尽管幼年CLI大鼠的食欲素水平下降，但与成年对照相比，具有抑郁特征的成年CLI大鼠的下丘脑食欲素水平明显较高。这些结果提示食欲素可能参与了抑郁症的病理调节。
Depression is associated with a deficiency of serotonergic neurons that have been found to suppress orexinergic neurons, which in turn activate these neurons in a feedback loop. This evidence suggests that orexins may be involved in the pathology of depression. Long Evans rats were treated with clomipramine (CLI) and saline (SAL) from postnatal days 8 through 21. One set of rats from both groups was sacrificed at 35 days of age for quantification of orexins in multiple brain regions. At 3–4 months of age a second set of rats was tested for immobility in a forced swim procedure, a common test for depressive signs in rats, and a third set was sacrificed for the quantification of orexins. Compared with the control rats, adult rats with neonatal CLI treatment had (1) increased forced swim immobility and (2) increased orexins A and B in the hypothalamus. However, both orexins A and B levels were decreased in multiple brain regions in the juvenile CLI rats compared with same-age controls. We concluded that although orexin levels were decreased in juvenile CLI rats, adult CLI rats with features of depression had significantly higher levels of hypothalamic orexins compared with adult controls. These results imply that orexins are likely to be involved in the pathological regulation of depression.
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DOI：
10.1016/0165-3806(83)90184-0
发表时间：
1983-01-01
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
MIRMIRAN, M;SCHOLTENS, J;BOER, GJ
通讯作者：
BOER, GJ
影响因子：
3.3
作者：
España, RA;Baldo, BA;Berridge, CW
通讯作者：
Berridge, CW
DOI：
10.1097/01.yic.0000195658.91524.61
发表时间：
2006-02-01
影响因子：
2.6
作者：
Lam, RW
通讯作者：
Lam, RW
影响因子：
2.9
作者：
Boldrini, M;Underwood, MD;Arango, V
通讯作者：
Arango, V
影响因子：
3
作者：
Lin, L;Wisor, J;Mignot, E
通讯作者：
Mignot, E