Common Dietary Modifications in Preclinical Models to Study Skeletal Health.
Common Dietary Modifications in Preclinical Models to Study Skeletal Health.
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DOI：
10.3389/fendo.2022.932343
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发表时间：
2022
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
--
作者：
骨是一种高度动态的组织，通过骨吸收破骨细胞和骨形成成骨细胞进行持续的重塑，这一过程在很大程度上由骨细胞调节。在更年期、2型糖尿病、神经性厌食症和慢性肾病的情况下，这些耦合的分解代谢和合成代谢过程的失调已知会增加骨折的风险。骨细胞代谢和生物能量学领域的最新进展表明，骨骼的维持对这些参与骨重塑的细胞有很高的能量需求。这些新的见解强调了骨组织是很大一部分心输出量和餐后乳糜微粒残留物的受益者，并且需要丰富的营养供应的原因。为研究饮食改变对骨骼稳态的影响或改变饮食组成和食物摄入以产生模型的特定目的而设计的研究可以在整个文献中找到；然而，在一些临床前模型中，混杂的饮食因素经常被忽视。本综述将研究一些用于研究骨骼生物学及其病理的常见临床前模型，以及各种饮食因素对这些模型系统的后续影响。此外，该综述将包括这些饮食成分的无意影响如何影响骨细胞功能和研究结果。
Bone is a highly dynamic tissue that undergoes continuous remodeling by bone resorbing osteoclasts and bone forming osteoblasts, a process regulated in large part by osteocytes. Dysregulation of these coupled catabolic and anabolic processes as in the case of menopause, type 2 diabetes mellitus, anorexia nervosa, and chronic kidney disease is known to increase fracture risk. Recent advances in the field of bone cell metabolism and bioenergetics have revealed that maintenance of the skeleton places a high energy demand on these cells involved in bone remodeling. These new insights highlight the reason that bone tissue is the beneficiary of a substantial proportion of cardiac output and post-prandial chylomicron remnants and requires a rich supply of nutrients. Studies designed for the specific purpose of investigating the impact of dietary modifications on bone homeostasis or that alter diet composition and food intake to produce the model can be found throughout the literature; however, confounding dietary factors are often overlooked in some of the preclinical models. This review will examine some of the common pre-clinical models used to study skeletal biology and its pathologies and the subsequent impact of various dietary factors on these model systems. Furthermore, the review will include how inadvertent effects of some of these dietary components can influence bone cell function and study outcomes.
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DOI：
10.1007/978-1-0716-1425-9_16
发表时间：
2021-01-01
期刊：
BONE MARROW ENVIRONMENT
影响因子：
--
作者：
Haltalli, Myriam L. R.;Lo Celso, Cristina
通讯作者：
Lo Celso, Cristina
DOI：
10.1016/j.vascn.2013.05.006
发表时间：
2013-09-01
影响因子：
1.9
作者：
Diwan, Vishal;Mistry, Anand;Brown, Lindsay
通讯作者：
Brown, Lindsay
影响因子：
39
作者：
Ensrud, Kristine E.;Kats, Allyson M.;Van Marter, J.
通讯作者：
Van Marter, J.
影响因子：
4
作者：
Gerdhem, P;Isaksson, A;Obrant, KJ
通讯作者：
Obrant, KJ
影响因子：
6.9
作者：
Bhaumik, Srabani;DePuy, Jeannette;Klimash, June
通讯作者：
Klimash, June