Associations between IQ, total and regional brain volumes, and demography in a large normative sample of healthy children and adolescents.
Associations between IQ, total and regional brain volumes, and demography in a large normative sample of healthy children and adolescents.
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DOI：
10.1080/87565641003696833
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发表时间：
2010
影响因子：
1.5
通讯作者：
Brain Development Cooperative Group
中科院分区：
文献类型：
--
作者：
Lange N;Froimowitz MP;Bigler ED;Lainhart JE;Brain Development Cooperative Group
在建立基于 MRI 的健康大脑发育定量标准的过程中，发现了以前未报道的父母教育、颞叶和额叶体积与全量表 IQ 及其语言和表现子量表之间的关联。我们的研究结果来自迄今为止最大、最具代表性的健康儿童和青少年的 MRI 样本，年龄为 4 岁 10 个月至 18 岁 4 个月。我们首先发现，父母教育与儿童智商有很强的相关性，而这种相关性不受总脑容量或区域脑容量的调节。其次，我们发现，我们观察到的儿童和青少年的颞叶灰质、颞叶白质和额叶白质体积与全量表智商（在 0.14 至 0.27 之间）之间的关联在很大程度上是由于它们与表现智商而不是言语智商的相关性。其他脑叶灰质和白质、皮质下灰质（丘脑、尾状核、壳核和苍白球）、小脑和脑干的体积对智商变化没有显着影响。第三，我们发现对于典型发育中的较大儿童和青少年来说，头围不足以衡量脑容量。当同时考虑与智商相关的已知变量，尤其是父母教育和其他人口统计指标时，可以最好地辨别总脑容量和局部脑容量与智商之间的关系。
In the course of efforts to establish quantitative MRI-based norms for healthy brain development, previously unreported associations of parental education and temporal and frontal lobe volumes with full scale IQ and its verbal and performance subscales were discovered. Our findings were derived from the largest, most representative MRI sample to date of healthy children and adolescents, ages 4 years 10 months to 18 years 4 months. We first find that parental education has a strong association with IQ in children that is not mediated by total or regional brain volumes. Second, we find that our observed associations between temporal gray matter, temporal white matter and frontal white matter volumes with full scale IQ, between 0.14 to 0.27 in children and adolescents, are due in large part to their correlations with performance IQ and not verbal IQ. The volumes of other lobar gray and white matter, subcortical gray matter (thalamus, caudate nucleus, putamen and globus pallidus), cerebellum and brainstem do not contribute significantly to IQ variation. Third, we find that head circumference is an insufficient index of cerebral volume in typically developing older children and adolescents. The relations between total and regional brain volumes and IQ can best be discerned when additional variables known to be associated with IQ, especially parental education and other demographic measures, are considered concurrently.
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影响因子：
9.9
作者：
Aylward, EH;Minshew, NJ;Singh, N
通讯作者：
Singh, N
DOI：
10.1196/annals.1308.058
发表时间：
2004-01-01
期刊：
ADOLESCENT BRAIN DEVELOPMENT: VULNERABILITIES AND OPPORTUNITIES
影响因子：
--
作者：
Juraska, JM;Markham, JA
通讯作者：
Markham, JA
影响因子：
4.8
作者：
Collins, DL;Holmes, CJ;Evans, AC
通讯作者：
Evans, AC
影响因子：
6.8
作者：
AKAIKE, H
通讯作者：
AKAIKE, H
影响因子：
3.6
作者：
Isaacs, Elizabeth B.;Gadian, David G.;Lucas, Alan
通讯作者：
Lucas, Alan