Metastable neural dynamics in Alzheimer's disease are disrupted by lesions to the structural connectome.
Metastable neural dynamics in Alzheimer's disease are disrupted by lesions to the structural connectome.
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DOI：
10.1016/j.neuroimage.2018.08.033
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发表时间：
2018-12
期刊：
影响因子：
5.7
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
中科院分区：
文献类型：
--
作者：
Alderson TH;Bokde ALW;Kelso JAS;Maguire L;Coyle D;Alzheimer's Disease Neuroimaging Initiative
目前的理论表明，大脑区域通过利用亚稳态动力学相互作用，以协调整合和隔离的竞争需求。一个新兴的共识认识到亚稳态在健康神经动力学中的重要性，其中网络状态之间的过渡取决于大脑区域之间的结构连接。在阿尔茨海默病（AD）-最常见的痴呆症形式-这些耦合逐渐减弱，神经动力学的亚稳定性降低，认知能力受损。因此，我们使用一个联合的经验和计算的方法来揭示神经亚稳态的行为相关的变化是偶然的解剖连接体的结构完整性。我们估计的亚稳定性的fMRI BOLD信号的受试者从整个AD频谱和健康对照组，并证明结构断开同步与亚稳定性的可分离的影响。此外，我们揭示了亚稳态在一般认知中的关键作用，通过展示个人的认知表现和他们的亚稳态神经动力之间的联系。最后，使用全脑计算机建模，我们展示了一个健康的神经动力学是如何取决于结构连接体的拓扑完整性。总的来说，我们的联合计算和实证分析的结果表明，亚稳态神经动力学，认知和解剖连接体的结构效率之间存在重要的因果关系。
Current theory suggests brain regions interact to reconcile the competing demands of integration and segregation by leveraging metastable dynamics. An emerging consensus recognises the importance of metastability in healthy neural dynamics where the transition between network states over time is dependent upon the structural connectivity between brain regions. In Alzheimer’s disease (AD) - the most common form of dementia - these couplings are progressively weakened, metastability of neural dynamics are reduced and cognitive ability is impaired. Accordingly, we use a joint empirical and computational approach to reveal how behaviourally relevant changes in neural metastability are contingent on the structural integrity of the anatomical connectome. We estimate the metastability of fMRI BOLD signal in subjects from across the AD spectrum and in healthy controls and demonstrate the dissociable effects of structural disconnection on synchrony versus metastability. In addition, we reveal the critical role of metastability in general cognition by demonstrating the link between an individuals cognitive performance and their metastable neural dynamic. Finally, using whole-brain computer modelling, we demonstrate how a healthy neural dynamic is conditioned upon the topological integrity of the structural con- nectome. Overall, the results of our joint computational and empirical analysis suggest an important causal relationship between metastable neural dynamics, cognition, and the structural efficiency of the anatomical connectome.
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影响因子：
4.3
作者：
Bressler SL;Kelso JA
通讯作者：
Kelso JA
影响因子：
5.7
作者：
Cabral, Joana;Hugues, Etienne;Deco, Gustavo
通讯作者：
Deco, Gustavo
DOI：
10.1073/pnas.1220826110
发表时间：
2013-07-09
影响因子：
11.1
作者：
Crossley, Nicolas A.;Mechelli, Andrea;Bullmore, Edward T.
通讯作者：
Bullmore, Edward T.
DOI：
10.1093/brain/awu132
发表时间：
2014-08
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Crossley NA;Mechelli A;Scott J;Carletti F;Fox PT;McGuire P;Bullmore ET
通讯作者：
Bullmore ET
DOI：
10.1177/1073858414525995
发表时间：
2014-12
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Cole MW;Repovš G;Anticevic A
通讯作者：
Anticevic A