The frontoparietal control system: a central role in mental health.

The frontoparietal control system: a central role in mental health.
复制标题

DOI:
10.1177/1073858414525995
复制
发表时间:
2014-12
期刊:
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子:
--
通讯作者:
Anticevic A
Anticevic A
中科院分区:
其他
文献类型:
--
作者:
Cole MW;Repovš G;Anticevic A

文献摘要

参考文献

被引文献

相似文献

最近的研究结果表明,存在一个由调节分布式系统的“灵活中枢”组成的额顶叶控制系统(例如,视觉、边缘系统、运动)。越来越多的研究报告了这种控制系统在一系列精神疾病中的改变。我们认为这可能反映了控制系统在促进和维持心理健康方面的关键作用。具体来说,我们建议该系统实现反馈控制,以在症状出现时对其进行调节(例如,通过调节杏仁核减少过度焦虑),这样一个完整的控制系统可以防止各种精神疾病。与这种可能性相一致的是,最近的研究结果表明,几种主要的精神疾病涉及控制系统的全脑连接改变,可能改变了其调节症状的能力。这些结果表明,这种“大脑免疫系统”可能是未来基础和临床研究的一个特别重要的目标。
Recent findings suggest the existence of a frontoparietal control system consisting of ‘flexible hubs’ that regulate distributed systems (e.g., visual, limbic, motor) according to current task goals. A growing number of studies are reporting alterations of this control system across a striking range of mental diseases. We suggest this may reflect a critical role for the control system in promoting and maintaining mental health. Specifically, we propose that this system implements feedback control to regulate symptoms as they arise (e.g., excessive anxiety reduced via regulation of amygdala), such that an intact control system is protective against a variety of mental illnesses. Consistent with this possibility, recent results indicate that several major mental illnesses involve altered brain-wide connectivity of the control system, likely altering its ability to regulate symptoms. These results suggest that this ‘immune system of the mind’ may be an especially important target for future basic and clinical research.
DOI: 10.1017/s0033291712000840
发表时间: 2013-01
影响因子: 6.9
作者:
Blair, K. S.;Vythilingam, M.;Crowe, S. L.;McCaffrey, D. E.;Ng, P.;Wu, C. C.;Scaramozza, M.;Mondillo, K.;Pine, D. S.;Charney, D. S.;Blair, R. J. R.
通讯作者: Blair, R. J. R.
DOI: 10.1016/j.biopsych.2009.10.031
发表时间: 2010-05-15
影响因子: 10.6
作者:
Browning, Michael;Holmes, Emily A.;Harmer, Catherine J.
通讯作者: Harmer, Catherine J.
DOI: 10.1016/j.cpr.2012.10.006
发表时间: 2013-02-01
影响因子: 12.8
作者:
Chiesa, Alberto;Serretti, Alessandro;Jakobsen, Janus Christian
通讯作者: Jakobsen, Janus Christian
DOI: 10.1016/j.schres.2012.07.007
发表时间: 2012-10
影响因子: 4.5
作者:
Anticevic A;Repovs G;Krystal JH;Barch DM
通讯作者: Barch DM
DOI: 10.1176/appi.ajp.163.3.418
发表时间: 2006-03-01
影响因子: 17.7
作者:
Bowie, CR;Reichenberg, A;Harvey, PD
通讯作者: Harvey, PD