Use and interpretation of microbiological assays in periodontal diseases.
Use and interpretation of microbiological assays in periodontal diseases.
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牙周病微生物检测的使用和解释。
DOI：
10.1111/j.1399-302x.1986.tb00324.x
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发表时间：
1986
影响因子：
--
通讯作者：
Christersson,LA
中科院分区：
文献类型：
--
作者：
Genco,RJ;Zambon,JJ;Christersson,LA
这份报告总结了其基本原理，并举例说明了微生物学检测在牙周疾病中对特定微生物的使用，如放线杆菌(嗜血杆菌)、放线菌伴生。关于OFA流行和监测的数据。本文报告了局限性青少年牙周炎(LJP)患者伴发放线菌的情况，60例LJP患者中有57例伴发放线菌，患病率为95%。在三名没有表现出这种有机体的患者中，有两名患者的血清抗体为ToA。放线菌伴生表明他们曾经被感染过。大量的OFA。在LJP患者中，三分之二或更多的牙周受累部位发现有放线菌伴生。微生物学和临床数据表明，为了确保成功的治疗，必须彻底根除这种微生物。对个别牙周炎患者的特定微生物进行微生物检测的一般方法可用于：(A)确定致病因素，(B)评估疾病活动以制定治疗计划，(C)监测治疗效果，以及(D)决定召回间隔。对于那些治疗没有成功的患者，对牙龈下菌群的细菌培养和抗生素敏感性的测定可能是有用的。快速检测在流行病学研究中也是有用的，以确定病原体在不同人群中的流行程度，在纵向研究中评估各种微生物在牙周病病因中的重要性，并识别牙周病初始发作或复发的高危人群。本文提供的数据和对相关文献的回顾有力地支持了将特定微生物的微生物检测作为牙周病诊断和治疗的辅助手段。显然，细致、长期的牙周菌斑控制和根面平整对于大多数牙周病的治疗是非常重要的，然而，特定微生物的鉴定和监测为牙周病的治疗提供了新的途径，并为治疗特定的牙周感染提供了理论基础。虽然尚未定义所有特定的牙周病原体，但已知足够数量的重要病原体，因此，有必要对这些微生物进行检测。此外，技术已经发展到了快速微生物检测可行和实用的地步。未来的发展可能会提供更有效和更好的测试。总之，对几种重要的牙周病原体进行评估的理论基础和目前使这种评估可行的技术水平，有力地支持了在各种形式的牙周病的临床治疗中使用微生物学检测作为辅助手段。
This report summarizes the rationale and illustrates the use of microbiological assays for specific microorganisms such asActinobacillus (Haemophilus) actinomycetemcomitansin periodontal diseases. Data on the prevalence and monitoring ofA. actinomycetemcomitansin patients with localized juvenile periodontitis (LJP) are presented.A. actinomycetemcomitanswas found in 57 of 60 LJP patients for a prevalence of 95%. Two of the three patients not demonstrating the organism had serum antibodies toA. actinomycetemcomitanssuggesting that they were once infected. Large numbers ofA. actinomycetemcomitanswere found in two‐thirds or more of the periodontally involved sites in the LJP patients. Microbiologic and clinical data illustrates the critical need for complete eradication of this organism in order to ensure successful therapy. The general use of microbiological tests for specific microorganisms in individual periodontitis patients can be applied to: (a) determine the causative agent, (b) assess disease activity for treatment planning, (c) monitor the effects of treatment, and (d) decide on recall intervals. Bacterial culture of the subgingival flora and determination of antibiotic susceptibility is likely to be useful in patients in whom therapy has not been successful. Rapid assays are also useful in examining subjects in epidemiologic studies to determine the prevalence of pathogens in various populations, in longitudinal studies to assess the importance of various microorganisms in the etiology of periodontal disease, and to identify persons at‐risk for either the initial episode of periodontal disease or for recurrent disease.The data presented here and the review of the relevant literature strongly support the use of microbiological assays for specific microorganisms as adjuncts in the diagnosis and management of periodontal disease. It is clear that meticulous, long‐term supragingival plaque control and root planing to achieve smooth surfaces of the roots is very important for the management of most forms of periodontal disease, however, identification and monitoring of specific microorganisms represents a new approach to the management of periodontal disease and provides a rationale for treatment of the specific infections of the periodontium. Although all of the specific periodontal pathogens have not been defined, a sufficient number of important pathogens are known and testing for these organisms is, therefore, indicated. Furthermore, technologies have developed to the point where rapid microbiological tests are feasible and practical. Future developments will likely provide more efficient and improved tests. In conclusion, the rationale for assessment of several important periodontal pathogens and the present level of technology making such assessment feasible, strongly support the use of microbiologic assays as adjuncts in the clinical management of various forms of periodontal disease.
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牙周病中的主要可培养微生物群。
影响因子：
3.5
作者：
Michael Newman;S. Socransky
通讯作者：
S. Socransky
幼年牙周炎伴放线杆菌和腐蚀艾肯菌的纵向微生物学研究
影响因子：
3.1
作者：
Robert L. Mandell;Forsyth
通讯作者：
Forsyth
通过间接荧光抗体技术检测龈下涂片中的伴放线放线杆菌和牙龈拟杆菌。
影响因子：
3.5
作者：
J. Slots;C. Hafström;B. Rosling;G. Dahlén
通讯作者：
G. Dahlén
影响因子：
6.7
作者：
J. S. Garrett
通讯作者：
J. S. Garrett
DOI：
--
发表时间：
1970
期刊：
Journal of dentistry research
影响因子：
--
作者：
S. Socransky
通讯作者：
S. Socransky