Inhibition of Plasmodium sporozoites infection by targeting the host cell.
Inhibition of Plasmodium sporozoites infection by targeting the host cell.
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DOI：
10.1016/j.exppara.2010.05.012
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发表时间：
2010-10
影响因子：
2.1
通讯作者：
Rodriguez, Ana
中科院分区：
文献类型：
--
作者：
Leitao, Ricardo;Rodriguez, Ana
关键词：
There is a great need of new drugs against malaria because of the increasing spread of parasite resistance against the most commonly used drugs in the field. We found that monensin, a common veterinary antibiotic, has a strong inhibitory effect in Plasmodium berghei and P. yoelii sporozoites hepatocyte infection in vitro. Infection of host cells by another apicomplexan parasite with a similar mechanism of host cell invasion, Toxoplasma tachyzoites, was also inhibited. Treatment of mice with monensin abrogates liver infection with P. berghei sporozoites in vivo. We also found that at low concentrations monensin inhibits the infection of Plasmodium sporozoites by rendering host cells resistant to infection, rather than having a direct effect on sporozoites. Monensin effect is targeted to the initial stages of parasite invasion of the host cell with little or no effect on development, suggesting that this antibiotic affects an essential host cell component that is required for Plasmodium sporozoite invasion.
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影响因子：
3.3
作者：
ZINN, RA;PLASCENCIA, A;BARAJAS, R
通讯作者：
BARAJAS, R
影响因子：
3.3
作者：
GOODRICH, RD;GARRETT, JE;MEISKE, JC
通讯作者：
MEISKE, JC
影响因子：
3.9
作者：
Gibot, S;Jeminet, G;Delort, AM
通讯作者：
Delort, AM
影响因子：
2
作者：
TSUJI, M;MATTEI, D;ZAVALA, F
通讯作者：
ZAVALA, F
影响因子：
56.9
作者：
Mota, MM;Pradel, G;Rodríguez, A
通讯作者：
Rodríguez, A