Review of Long-Wavelength Optical and NIR Imaging Materials: Contrast Agents, Fluorophores and Multifunctional Nano Carriers.
Review of Long-Wavelength Optical and NIR Imaging Materials: Contrast Agents, Fluorophores and Multifunctional Nano Carriers.
复制标题
DOI：
10.1021/cm2028367
复制
发表时间：
2012-03-13
影响因子：
8.6
通讯作者：
Prud'homme, Robert K.
中科院分区：
文献类型：
--
作者：
Pansare, Vikram J.;Hejazi, Shahram;Faenza, William J.;Prud'homme, Robert K.
关键词：
由于需要进行整体动物和深层组织成像，长波和近红外(NIR)成像的重要性大大增加。由于可用于诊断和可在体内成像的基础医学研究的靶向生物制剂的可用性，近红外成像的采用也迅速增长。650-1450 nm的波长范围落在组织中吸收最低的光谱区域，因此能够实现最深的组织渗透。这就是我们在这篇评论中关注的波长范围。为了有效地工作，成像剂必须既被激发又必须在这个长波长窗口中发射。我们回顾了用于吸收成像、散射成像和激发成像(如荧光)成像的试剂。显像剂包括水溶和不溶物种，包括有机和无机，以及单分子和超分子结构。对多模式成像的兴趣，包括活性物质的传递、靶向和成像，需要纳米载体或超分子组装。与单分子显像剂相比，用于诊断的纳米颗粒在延长循环时间和提高成像亮度方面也具有优势。这导致了用于长波长近红外成像的纳米载体的快速发展。
The importance of long wavelength and near infra-red (NIR) imaging has dramatically increased due to the desire to perform whole animal and deep tissue imaging. The adoption of NIR imaging is also growing rapidly due to the availability of targeted biological agents for diagnosis and basic medical research that can be imaged in vivo. The wavelength range of 650–1450 nm falls in the region of the spectrum with the lowest absorption in tissue and therefore enables the deepest tissue penetration. This is the wavelength range we focus on with this review. To operate effectively the imaging agents must both be excited and must emit in this long-wavelength window. We review the agents used both for imaging by absorption, scattering, and excitation (such as fluorescence). Imaging agents comprise both aqueous soluble and insoluble species, both organic and inorganic, and unimolecular and supramolecular constructs. The interest in multi-modal imaging, which involves delivery of actives, targeting, and imaging, requires nanocarriers or supramolecular assemblies. Nanoparticles for diagnostics also have advantages in increasing circulation time and increased imaging brightness relative to single molecule imaging agents. This has led to rapid advances in nanocarriers for long-wavelength, NIR imaging.
登录
查看更多内容
影响因子：
3.8
作者：
Demos, SG;Radousky, HB;Alfano, RR
通讯作者：
Alfano, RR
影响因子：
19
作者：
Akbulut, Mustafa;Ginart, Paul;Prud'homme, Robert K.
通讯作者：
Prud'homme, Robert K.
影响因子：
2.1
作者：
BOULNOIS J-L
通讯作者：
BOULNOIS J-L
影响因子：
--
作者：
Bousalem, S;Benabderrahmane, S;Chehimi, MM
通讯作者：
Chehimi, MM
影响因子：
56.9
作者：
Bachilo, SM;Strano, MS;Weisman, RB
通讯作者：
Weisman, RB