Uberon, an integrative multi-species anatomy ontology.

Uberon, an integrative multi-species anatomy ontology.
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DOI:
10.1186/gb-2012-13-1-r5
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发表时间:
2012-01-31
期刊:
影响因子:
12.3
通讯作者:
Haendel MA
Haendel MA
中科院分区:
生物学1区
文献类型:
--
作者:
Mungall CJ;Torniai C;Gkoutos GV;Lewis SE;Haendel MA

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我们提出了Uberon,一个综合的跨物种本体论,包括6,500多个类,代表各种解剖实体,根据传统的解剖分类标准组织。该本体以物种中立的方式表示结构,并包括与现有的以物种为中心的解剖本体的广泛关联,允许模型生物和人类数据的集成。Uberon在不同类群的解剖结构之间提供了一个必要的桥梁,用于跨种推断。它使用新的方法来表示分类变异,并已被证明是必不可少的翻译表型分析。Uberon可在http://uberon.org上获得
We present Uberon, an integrated cross-species ontology consisting of over 6,500 classes representing a variety of anatomical entities, organized according to traditional anatomical classification criteria. The ontology represents structures in a species-neutral way and includes extensive associations to existing species-centric anatomical ontologies, allowing integration of model organism and human data. Uberon provides a necessary bridge between anatomical structures in different taxa for cross-species inference. It uses novel methods for representing taxonomic variation, and has proved to be essential for translational phenotype analyses. Uberon is available at http://uberon.org
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