Update on the magnetic resonance imaging core of the Alzheimer's disease neuroimaging initiative.
Update on the magnetic resonance imaging core of the Alzheimer's disease neuroimaging initiative.
复制标题
阿尔茨海默病神经影像计划的磁共振成像核心的最新信息。
DOI：
10.1016/j.jalz.2010.03.004
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发表时间：
2010-05
影响因子：
14
通讯作者：
Weiner, Michael W.
中科院分区：
文献类型：
--
作者：
Jack, Clifford R., Jr.;Bernstein, Matt A.;Borowski, Bret J.;Gunter, Jeffrey L.;Fox, Nick C.;Thompson, Paul M.;Schuff, Norbert;Krueger, Gunnar;Killiany, Ronald J.;DeCarli, Charles S.;Dale, Anders M.;Carmichael, Owen W.;Tosun, Duygu;Weiner, Michael W.
ADNI MRI 核心的功能分为三类：(1) 位于明尼苏达州罗切斯特市 Mayo Clinic 的中央 MRI 核心实验室的功能，需要在每个时间点为所有受试者生成高质量的 MRI 数据； （2）资助的ADNI MRI核心成像分析小组负责分析MRI数据，以及（3）整个MRI核心在设计和解决MR图像采集、预处理和分析方法中的联合功能。 ADNI 的主要目标过去是、现在仍然是改进阿尔茨海默病临床试验的方法。我们对当前（“ADNI-GO”）和未来（“ADNI-2”，如果有资助）MRI 方案的方法将是保持先前登记的“ADNI-1”受试者的 MRI 方法学一致性，这些受试者在 ADNI-GO 和 ADNI-2 中进行纵向随访。我们将为所有新注册的 ADNI-GO 和 ADNI-2 受试者更新并扩展 MRI 协议。所有新登记的受试者都将使用一组核心的三种序列类型进行 3T 扫描：3D T1 加权体积、FLAIR 和用于微出血检测的长 TE 梯度回波体积采集。除了核心 ADNI-GO 和 ADNI-2 协议之外，我们还将执行供应商特定的动脉自旋标记灌注、静息状态功能连接和扩散张量成像的试点子研究。这些序列中的每一个都将被添加到每个 MRI 供应商系统的核心协议中。这些实验子研究旨在证明在多中心（但单一供应商）环境中为这三种新兴 MRI 应用获取有用数据的可行性。
Functions of the ADNI MRI core fall into three categories: (1) those of the central MRI core lab at Mayo Clinic, Rochester, Minnesota, needed to generate high quality MRI data in all subjects at each time point; (2) those of the funded ADNI MRI core imaging analysis groups responsible for analyzing the MRI data, and (3) the joint function of the entire MRI core in designing and problem solving MR image acquisition, pre-processing and analyses methods. The primary objective of ADNI was and continues to be improving methods for clinical trials in Alzheimer's disease. Our approach to the present (“ADNI-GO”) and future (“ADNI-2”, if funded) MRI protocol will be to maintain MRI methodological consistency in previously enrolled “ADNI-1” subjects who are followed longitudinally in ADNI-GO and ADNI-2. We will modernize and expand the MRI protocol for all newly enrolled ADNI-GO and ADNI-2 subjects. All newly enrolled subjects will be scanned at 3T with a core set of three sequence types: 3D T1-weighted volume, FLAIR, and a long TE gradient echo volumetric acquisition for micro hemorrhage detection. In addition to this core ADNI-GO and ADNI-2 protocol, we will perform vendor specific pilot sub-studies of arterial spin labeling perfusion, resting state functional connectivity and diffusion tensor imaging. One each of these sequences will be added to the core protocol on systems from each MRI vendor. These experimental sub-studies are designed to demonstrate the feasibility of acquiring useful data in a multi-center (but single vendor) setting for these three emerging MRI applications.
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影响因子：
5.7
作者：
Chen, Kewei;Langbaum, Jessica B. S.;Fleisher, Adam S.;Ayutyanont, Napatkamon;Reschke, Cole;Lee, Wendy;Liu, Xiaofen;Bandy, Dan;Alexander, Gene E.;Thompson, Paul M.;Foster, Norman L.;Harvey, Danielle J.;de Leon, Mony J.;Koeppe, Robert A.;Jagust, William J.;Weiner, Michael W.;Reiman, Eric M.
通讯作者：
Reiman, Eric M.
影响因子：
3.8
作者：
Gunter, Jeffrey L.;Bernstein, Matt A.;Jack, Clifford R.
通讯作者：
Jack, Clifford R.
DOI：
10.1523/jneurosci.3785-09.2010
发表时间：
2010-02-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fjell AM;Walhovd KB;Fennema-Notestine C;McEvoy LK;Hagler DJ;Holland D;Brewer JB;Dale AM;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI
影响因子：
5.9
作者：
Evans, Matthew C.;Barnes, Josephine;Fox, Nick C.
通讯作者：
Fox, Nick C.