A self-assembly pathway to aligned monodomain gels.
A self-assembly pathway to aligned monodomain gels.
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作者：
已发现带电两亲性分子的聚集体在高温下形成一种结构，该结构在宏观尺度上模板超分子原纤维的排列。热路径导致具有纤维纹理的层状斑块结构，该结构在冷却时破裂成大阵列的对齐纳米级纤维并形成强双折射液体。通过手动将这种液晶从移液器拖到含盐介质上，可以将这种排列在面条状粘弹性线中延伸到厘米以上。使用这种方法，超分子丝的溶液可以在生理温度下与细胞混合，形成排列的细胞和丝的单域凝胶。自组装过程的性质及其生物相容性将允许原位形成具有任意长度和定制肽组成的细胞线，用于生物应用。
Aggregates of charged amphiphilic molecules have been found to access a structure at elevated temperature that templates alignment of supramolecular fibrils over macroscopic scales. The thermal pathway leads to a lamellar plaque structure with fibrous texture that breaks upon cooling into large arrays of aligned nanoscale fibres and forms a strongly birefringent liquid. By manually dragging this liquid crystal from a pipette onto salty media, it is possible to extend this alignment over centimetres in noodle-shaped viscoelastic strings. Using this approach, the solution of supramolecular filaments can be mixed with cells at physiological temperatures to form monodomain gels of aligned cells and filaments. The nature of the self-assembly process and its biocompatibility would allow formation of cellular wires in situ that have any length and customized peptide compositions for use in biological applications.
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DOI：
10.1111/j.1540-8167.2007.00959.x
发表时间：
2007-12-01
影响因子：
2.7
作者：
Chung, Chiung-Yin;Bien, Harold;Entcheva, Emilia
通讯作者：
Entcheva, Emilia
影响因子：
4.6
作者：
DEWIT, A;GALLEZ, D;CHRISTOV, CI
通讯作者：
CHRISTOV, CI
影响因子：
2.4
作者：
Lenz, P;Nelson, DR
通讯作者：
Nelson, DR
影响因子：
4.7
作者：
Bull, SR;Guler, MO;Meade, TJ
通讯作者：
Meade, TJ
影响因子：
3.4
作者：
Cheng, H;Zhang, K;Bedzyk, MJ
通讯作者：
Bedzyk, MJ