Association of Aortic Stiffness and Cognitive Decline: A Systematic Review and Meta-Analysis.
Association of Aortic Stiffness and Cognitive Decline: A Systematic Review and Meta-Analysis.
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主动脉僵硬与认知能力下降的关联：系统回顾和荟萃分析
DOI：
10.3389/fnagi.2021.680205
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发表时间：
2021
影响因子：
4.8
通讯作者：
He L
中科院分区：
文献类型：
--
作者：
Liu Q;Fang J;Cui C;Dong S;Gao L;Bao J;Li Y;Ma M;Chen N;He L
背景：已发现主动脉僵硬增加与认知功能下降有关，但证据仍在争论中。阐明这场辩论中的证据对于在我们的常规临床实践中帮助做出减缓认知衰退的初级预防决策具有重要意义。方法：系统检索PubMed、EMBASE和Cochrane图书馆1986年1月1日至2020年3月16日发表的有关主动脉僵硬与认知功能相关的同行评议文章，检索词为英文。报告主动脉脉搏波速度(PWV)与认知功能、认知障碍和痴呆症的相关性的研究被纳入分析范围。结果：定性分析纳入39篇，定量分析纳入29篇。在横断面分析中，主动脉PWV与记忆和处理速度呈负相关。纵向分析显示，与低PWV相比，高PWV组认知损害风险增加44%(OR1.44；95%CI1.24~1.85)，认知损害风险每增加1 m/S增加3.9%(OR 1.039；95%CI 1.005~1.073)。此外，Meta回归分析显示，年龄显著增加了高主动脉PWV与认知损害风险之间的关联。结论：主动脉PWV测定的主动脉僵硬与记忆和处理速度呈负相关，可作为认知损害的独立预测指标，尤其是对老年人。
Background: Increased aortic stiffness has been found to be associated with cognitive function decline, but the evidence is still under debate. It is of great significance to elucidate the evidence in this debate to help make primary prevention decisions to slow cognitive decline in our routine clinical practice. Methods: Electronic databases of PubMed, EMBASE, and Cochrane Library were systematically searched to identify peer-reviewed articles published in English from January 1, 1986, to March 16, 2020, that reported the association between aortic stiffness and cognitive function. Studies that reported the association between aortic pulse wave velocity (PWV) and cognitive function, cognitive impairment, and dementia were included in the analysis. Results: Thirty-nine studies were included in the qualitative analysis, and 29 studies were included in the quantitative analysis. The aortic PWV was inversely associated with memory and processing speed in the cross-sectional analysis. In the longitudinal analysis, the high category of aortic PWV was 44% increased risk of cognitive impairment (OR 1.44; 95% CI 1.24–1.85) compared with low PWV, and the risk of cognitive impairment increased 3.9% (OR 1.039; 95% CI 1.005–1.073) per 1 m/s increase in aortic PWV. Besides, meta-regression analysis showed that age significantly increased the association between high aortic PWV and cognitive impairment risk. Conclusion: Aortic stiffness measured by aortic PWV was inversely associated with memory and processing speed and could be an independent predictor for cognitive impairment, especially for older individuals.
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DOI：
10.1016/s0140-6736(17)31363-6
发表时间：
2017-12-16
期刊：
Lancet (London, England)
影响因子：
--
作者：
Livingston, Gill;Sommerlad, Andrew;Mukadam, Naaheed
通讯作者：
Mukadam, Naaheed
影响因子：
5.3
作者：
Geijselaers, Stefan L. C.;Sep, Simone J. S.;Stehouwer, Coen D. A.
通讯作者：
Stehouwer, Coen D. A.
影响因子：
4
作者：
Lim, Shir Lynn;Gao, Qi;Ng, Tze Pin
通讯作者：
Ng, Tze Pin
影响因子：
120.7
作者：
Langa, Kenneth M.;Levine, Deborah A.
通讯作者：
Levine, Deborah A.
影响因子：
6
作者：
Kim ED;Meoni LA;Jaar BG;Shafi T;Linda Kao WH;Estrella MM;Parekh R;Sozio SM
通讯作者：
Sozio SM