Increased Postprandial Colonic Motility and Autonomic Nervous System Activity in Patients With Irritable Bowel Syndrome: A Prospective Study.
Increased Postprandial Colonic Motility and Autonomic Nervous System Activity in Patients With Irritable Bowel Syndrome: A Prospective Study.
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DOI：
10.5056/jnm16216
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发表时间：
2018-01-30
影响因子：
3.4
通讯作者：
Whitehead WE
中科院分区：
文献类型：
--
作者：
Tanaka Y;Kanazawa M;Palsson OS;Tilburg MAV;Gangarosa LM;Fukudo S;Drossman DA;Whitehead WE
肠易激综合症（IBS）的患病率和严重程度随着年龄的增长而下降，但其原因尚不清楚。这项研究测试了 2 个假设：(1) 通过心率变异性 (HRV) 测量的自主神经系统对饮食和肠扩张的反应因 IBS 患者年龄的不同而不同；(2) HRV 与结肠运动和 IBS 症状相关。 156 名罗马 III 阳性 IBS 患者和 31 名健康对照者接受了结肠测压，降结肠袋扩张，然后摄入 810 kcal 的食物。在结肠扩张期间和餐后测量 HRV，通过低频（%LF；0.04–0.15 Hz）分量、高频（%HF；0.15–0.40 Hz）分量和 LF/HF 比来评估。同时量化运动指数和主观症状评分。结肠扩张和进食均降低 %HF 并增加 LF/HF 比值，并且这两项自主神经系统指标均与年龄相关。在 IBS 患者中，调整年龄后，％HF 与餐后运动指数呈负相关。 ％HF 和 LF/HF 比率也与 IBS 患者的心理症状相关，但与肠道症状无关。迷走神经活动减少与 IBS 患者年龄的增加和餐后结肠运动的增强有关，这可能会导致餐后症状。
The prevalence and severity of irritable bowel syndrome (IBS) declines with age, but the cause of this is unknown. This study tested 2 hypotheses: (1) autonomic nervous system responses to eating and bowel distention, measured by heart rate variability (HRV), differs by age in IBS patients and (2) HRV is correlated with colonic motility and IBS symptoms. One hundred and fifty-six Rome III positive IBS patients and 31 healthy controls underwent colonic manometry with bag distention in the descending colon, followed by ingestion of an 810-kcal meal. HRV, evaluated by low frequency (%LF; 0.04–0.15 Hz) component, high frequency (%HF; 0.15–0.40 Hz) component, and the LF/HF ratio, was measured during colonic distention and after the meal. Motility index and subjective symptom scores were simultaneously quantified. Both colonic distention and eating decreased %HF and increased the LF/HF ratio, and both indices of autonomic nervous system correlated with age. In IBS patients, %HF negatively correlated with the postprandial motility index after adjusting for age. The %HF and LF/HF ratios also correlated with psychological symptoms but not bowel symptoms in IBS patients. Decreased vagal activity is associated with increase in age and greater postprandial colonic motility in patients with IBS, which may contribute to postprandial symptoms.
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DOI：
10.1016/0165-1838(91)90113-h
发表时间：
1991-03-01
期刊：
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM
影响因子：
--
作者：
KORKUSHKO, OV;SHATILO, VB;SHATILO, TV
通讯作者：
SHATILO, TV
影响因子：
9.8
作者：
Adeyemi, EOA;Desai, KD;Ghista, D
通讯作者：
Ghista, D
影响因子：
24.5
作者：
Dorn, Spencer D.;Palsson, Olafur S.;Whitehead, William E.
通讯作者：
Whitehead, William E.
影响因子：
3.5
作者：
Jarrett, M. E.;Han, C. J.;Heitkemper, M. M.
通讯作者：
Heitkemper, M. M.
影响因子：
7.6
作者：
Hungin, APS;Whorwell, PJ;Mearin, F
通讯作者：
Mearin, F