Network Pharmacology-Based Study on the Mechanism of Scutellariae Radix for Hepatocellular Carcinoma Treatment.
Network Pharmacology-Based Study on the Mechanism of Scutellariae Radix for Hepatocellular Carcinoma Treatment.
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基于网络药理学的黄芩治疗肝癌机制研究
DOI：
10.1155/2020/8897918
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Jiang P
中科院分区：
文献类型：
--
作者：
Wang Q;Liang Y;Peng C;Jiang P
肝细胞癌（HCC）是一种恶性肿瘤，对于大多数晚期患者来说尚无有效的治疗药物。黄芩（SR）是一种著名的抗炎和抗癌草药。然而，SR抗HCC的机制仍有待阐明。在本研究中，利用网络药理学来表征SR对HCC的作用机制。 SR的活性成分及其作用靶点均来自中药系统药理学数据库和中药综合数据库。 HCC 相关靶标是从肝癌数据库 OncoDB.HCC 和 Liverome 获取的。使用注释、可视化和综合发现数据库对基因本体论和京都基因和基因组百科全书途径进行了分析。建立了成分-成分靶点和蛋白质-蛋白质相互作用网络。共鉴定出 SR 的 143 个成分，其中 37 个被认为是候选活性成分。对应于 SR 29 个组成部分的 50 个目标与 HCC 目标进行了映射。功能富集分析表明，SR 通过调节癌症、乙型肝炎、病毒致癌和 PI3K-Akt 信号传导途径发挥抗肝癌作用。网络药理学的整体方法可以为 SR 治疗 HCC 的机制研究和治疗药物开发提供新的见解。
Hepatocellular carcinoma (HCC) is a malignant tumor without effective therapeutic drugs for most patients in advanced stages. Scutellariae Radix (SR) is a well-known anti-inflammatory and anticarcinogenic herbal medicine. However, the mechanism of SR against HCC remains to be clarified. In the present study, network pharmacology was utilized to characterize the mechanism of SR on HCC. The active components of SR and their targets were collected from the traditional Chinese medicine systems pharmacology database and the traditional Chinese medicine integrated database. HCC-related targets were acquired from the liver cancer databases OncoDB.HCC and Liverome. The gene ontology and the Kyoto Encyclopedia of Genes and Genomes pathway were analyzed using the Database for Annotation, Visualization, and Integrated Discovery. Component-component target and protein-protein interaction networks were set up. A total of 143 components of SR were identified, and 37 of them were considered as candidate active components. Fifty targets corresponding to 29 components of SR were mapped with targets of HCC. Functional enrichment analysis indicated that SR exerted an antihepatocarcinoma effect by regulating pathways in cancer, hepatitis B, viral carcinogenesis, and PI3K-Akt signaling. The holistic approach of network pharmacology can provide novel insights into the mechanistic study and therapeutic drug development of SR for HCC treatment.
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