Synthesis and morphological characterization of block copolymers for improved biomaterials.
Synthesis and morphological characterization of block copolymers for improved biomaterials.
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DOI：
10.1016/j.ultramic.2010.02.025
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发表时间：
2010-05
期刊：
影响因子：
2.2
通讯作者：
Bhushan, Bharat
中科院分区：
文献类型：
--
作者：
Schricker, Scott;Palacio, Manuel;Thirumamagal, B. T. S.;Bhushan, Bharat
已知生物相容性聚合物可作为骨再生和生长的支架。嵌段共聚物作为支架材料是令人感兴趣的，因为许多嵌段是生物相容的，并且它们的纳米结构易于用合成技术调节。在本文中，我们报道了一类新的生物材料的合成从嵌段共聚物含有甲基丙烯酸甲酯的疏水嵌段和丙烯酸，二甲基丙烯酰胺，或2-羟乙基甲基丙烯酸酯的亲水嵌段。使用可逆加成-断裂链转移（RAFT）聚合和点击化学的组合来合成嵌段共聚物。由于表面形态是成功的细胞生长的关键，原子力显微镜（AFM）的研究进行了选定的嵌段共聚物。在干燥和生理缓冲环境中获得了形貌图、相位角图和摩擦力图，以研究其形态。AFM成像的结果确定了对应于共聚物组分的聚合物域的存在。这些嵌段共聚物中纳米级特征的分布与在表现出有利的细胞粘附和生长的其他表面上发现的那些特征相当。在生理缓冲介质中，由于吸水和溶胀，嵌段共聚物的亲水组分（丙烯酸或甲基丙烯酸羟乙酯）似乎以更大量存在于表面上。
Biocompatible polymers are known to act as scaffolds for the regeneration and growth of bone. Block copolymers are of interest as scaffold materials because a number of the blocks are biocompatible, and their nanostructure is easily tunable with synthetic techniques. In this paper, we report the synthesis of a novel class of biomaterials from block copolymers containing a hydrophobic block of methyl methacrylate and a hydrophilic block of either acrylic acid, dimethyl acrylamide, or 2-hydroxyethyl methacrylate. The block copolymers were synthesized using a combination of reversible addition-fragmentation chain transfer (RAFT) polymerization and click chemistry. Since the surface morphology is critical for successful cell growth, atomic force microscopy (AFM) studies were conducted for selected block copolymers. The topography, phase angle and friction maps were obtained in dry and physiological buffer environments to study the morphology. Results of AFM imaging identified the presence of polymer domains corresponding to the copolymer components. The distribution of nanoscale features in these block copolymers are comparable to those found on other surfaces that exhibit favorable cell adhesion and growth. In physiological buffer medium, the hydrophilic component of the block copolymer (acrylic acid or hydroxyethyl methacrylate) appear to be present in greater amounts on the surface as a consequence of water absorption and swelling.
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影响因子：
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作者：
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