Evidence and mechanisms of fat depletion in cancer.
Evidence and mechanisms of fat depletion in cancer.
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DOI：
10.3390/nu6115280
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发表时间：
2014-11-19
期刊：
影响因子：
5.9
通讯作者：
Mazurak VC
中科院分区：
文献类型：
--
作者：
Ebadi M;Mazurak VC
大多数癌症患者经历以肌肉损失为特征的消瘦，伴有或不伴有脂肪损失。在人类和动物癌症模型中，身体成分评估和形态学分析揭示了脂肪萎缩和较小脂肪细胞的存在。脂肪减少与癌症患者生活质量降低和生存期缩短相关，与体重指数无关。脂肪损失发生在内脏和皮下贮库;然而，损失的模式已不完全的特点。脂肪分解和脂肪氧化增加，脂肪生成减少，脂质沉积和脂肪生成受损，以及白色脂肪组织的布朗宁可能是癌症中脂肪萎缩的基础。肿瘤或脂肪组织产生的炎性细胞因子如白细胞介素-6（IL-6）、肿瘤坏死因子α（TNF-α）和白细胞介素-1 β（IL-1β）也可能导致脂肪消耗。确定癌症中脂肪量变化的机制和时间过程可能有助于确定有脂肪消耗风险的个体，并确定避免浪费的干预措施。这篇综述概述了目前对癌症中脂肪量的认识，并说明了进一步研究的必要性，以评估内脏和皮下脂肪库的变化以及癌症进展过程中脂肪损失的可能机制。
The majority of cancer patients experience wasting characterized by muscle loss with or without fat loss. In human and animal models of cancer, body composition assessment and morphological analysis reveals adipose atrophy and presence of smaller adipocytes. Fat loss is associated with reduced quality of life in cancer patients and shorter survival independent of body mass index. Fat loss occurs in both visceral and subcutaneous depots; however, the pattern of loss has been incompletely characterized. Increased lipolysis and fat oxidation, decreased lipogenesis, impaired lipid depositionand adipogenesis, as well as browning of white adipose tissue may underlie adipose atrophy in cancer. Inflammatory cytokines such as interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and interleukin-1 beta (IL-1β) produced by the tumor or adipose tissue may also contribute to adipose depletion. Identifying the mechanisms and time course of fat mass changes in cancer may help identify individuals at risk of adipose depletion and define interventions to circumvent wasting. This review outlines current knowledge of fat mass in cancer and illustrates the need for further studies to assess alterations in visceral and subcutaneous adipose depots and possible mechanisms for loss of fat during cancer progression.
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影响因子：
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