Fluorescent probes based on nucleophilic aromatic substitution reactions for reactive sulfur and selenium species: Recent progress, applications, and design strategies.
Fluorescent probes based on nucleophilic aromatic substitution reactions for reactive sulfur and selenium species: Recent progress, applications, and design strategies.
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基于活性硫和硒物质的亲核芳香取代反应的荧光探针：最新进展、应用和设计策略
DOI：
10.1016/j.ccr.2020.213601
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发表时间：
2021-01-15
影响因子：
20.6
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Liu Y;Yu Y;Zhao Q;Tang C;Zhang H;Qin Y;Feng X;Zhang J
综述了近年来基于SNAr反应的RSS和RSeS荧光探针的研究进展。讨论了基于SNAr反应的RSS和RSeS荧光探针的应用。综述了基于SNAr反应的RSS和RSeS荧光探针的设计策略。活性硫和活性硒是维持机体生理平衡的重要物质。RSS和RSeS的失衡与一系列人类疾病密切相关，因此被认为是早期诊断、治疗和阶段监测的重要生物标志物。快速准确地定量分析复杂生物系统中不同的RSS和RSeS可能会促进未来个性化诊断和治疗的发展。探索各种类型的RSS和RSeS在体内的生理功能的一种方法是在分子水平上检测它们，其中最有效的方法之一是使用荧光探针。亲核芳族取代（SNAr）反应通常被用作荧光探针中RSS和RSeS的检测机制。本文综述了近年来基于SNAr反应的RSS和RSeS荧光探针的研究进展，并讨论了它们的响应机制、性质和应用。苯磺酸根、苯氧醚、苯硫醚、苯硒醚、7-硝基-2，1，3-苯并恶二唑（NBD）、苯甲酸根和硒氮键都是很好的检测基团。此外，基于不同的报告的整合，我们提出了RSS和RSeS选择性探针的设计和合成的基础上SNAr反应，目前面临的挑战，和未来的研究方向，考虑到活性位点的选择，取代基对苯环的影响，并引入其他官能团。
Recent developments in the field of fluorescent probes for RSS and RSeS based on SNAr reactions are reviewed. Applications of fluorescent probes for RSS and RSeS based on SNAr reactions are discussed. Design strategies of fluorescent probes for RSS and RSeS based on SNAr reactions are summarized. Reactive sulfur species (RSS) and reactive selenium species (RSeS) are important substances for the maintenance of physiological balance. Imbalance of RSS and RSeS is closely related to a series of human diseases, so it is considered to be an important biomarker in early diagnosis, treatment, and stage monitoring. Fast and accurate quantitative analysis of different RSS and RSeS in complex biological systems may promote the development of personalized diagnosis and treatment in the future. One way to explore the physiological function of various types of RSS and RSeS in vivo is to detect them at the molecular level, and one of the most effective methods for this is to use fluorescent probes. Nucleophilic aromatic substitution (SNAr) reactions are commonly exploited as a detection mechanism for RSS and RSeS in fluorescent probes. In this review, we cover recent progress in fluorescent probes for RSS and RSeS based on SNAr reactions, and discuss their response mechanisms, properties, and applications. Benzenesulfonate, phenyl-O ether, phenyl-S ether, phenyl-Se ether, 7-nitro-2,1,3-benzoxadiazole (NBD), benzoate, and selenium-nitrogen bonds are all good detection groups. Moreover, based on an integration of different reports, we propose the design and synthesis of RSS- and RSeS-selective probes based on SNAr reactions, current challenges, and future research directions, considering the selection of active sites, the effect of substituents on the benzene ring, and the introduction of other functional groups.
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影响因子：
4
作者：
Chyan W;Raines RT
通讯作者：
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影响因子：
8.4
作者：
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影响因子：
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