Association of bone morphogenetic protein-2 gene polymorphisms with susceptibility to ossification of the posterior longitudinal ligament of the spine and its severity in Chinese patients.
Association of bone morphogenetic protein-2 gene polymorphisms with susceptibility to ossification of the posterior longitudinal ligament of the spine and its severity in Chinese patients.
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中国患者骨形态发生蛋白2基因多态性与脊柱后纵韧带骨化易感性及其严重程度的关系
DOI：
10.1007/s00586-008-0651-8
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发表时间：
2008-07
影响因子：
2.8
通讯作者：
Lin, Xin
中科院分区：
文献类型：
--
作者：
Wang, Hao;Liu, Dongmei;Yang, Zhaohui;Tian, Baopeng;Li, Jie;Meng, Xianglong;Wang, Zhentian;Yang, Hui;Lin, Xin
本研究采用病例对照研究方法，探讨骨形态发生蛋白2（BMP-2）基因外显子2的两个单核苷酸多态性（SNP）与后纵韧带骨化（OPLL）的关系，并研究BMP-2基因中Ser 37 Ala（T/G）和Ser 87 Ser（A/G）的SNPs是否与BMP-2基因的表达有关。2基因与OPLL的遗传易感性及严重程度相关。Ser 87 Ser（A/G）SNP与骨矿物质密度（BMD）有关，并增加女性患OA的风险。Ser 37 Ala（T/G）SNP与骨质疏松症和骨质疏松性骨折的BMD和骨丢失率相关。共研究了57例OPLL患者和135例非OPLL对照。分析颈椎X线片以确定OPLL的存在和严重程度。统计分析两个SNPs与OPLL发生和程度的关系。Ser 37 Ala（T/G）多态性与颈椎OPLL的发生有显著相关性。然而，未发现Ser 37 Ala（T/G）多态性与OPLL患者颈椎骨化数量增加之间存在显著相关性。OPLL患者中Ser 87 Ser（A/G）多态性与颈椎骨化数量增加显著相关。而Ser 87 Ser（A/G）SNP与颈椎OPLL的发生率无统计学差异。此外，男性患者和女性患者的Ser 87 Ser（A/G）多态性在病例组和对照组之间均无统计学差异。本研究结果表明，BMP-2基因不仅与OPLL的发生有关，而且与更广泛的OPLL有关。Ser 37 Ala（T/G）多态性中的“G”等位基因与OPLL的发生相关，但与颈椎更广泛的OPLL无关。Ser 87 Ser（A/G）多态性中的“G”等位基因促进OPLL的程度，而Ser 87 Ser（A/G）多态性中的“A”等位基因至少在中国人中限制颈椎异位骨化。
A case–control study was conducted to examine the association between two single nucleotide polymorphisms (SNPs) in exon 2 of the bone morphogenetic protein-2 gene (BMP-2) and ossification of the posterior longitudinal ligament (OPLL), and to investigate whether SNPs of the Ser37Ala (T/G) and the Ser87Ser (A/G) in the BMP-2 gene are associated with genetic susceptibility to OPLL and its severity in Chinese subjects. The Ser87Ser (A/G) SNP has been implicated in bone mineral density (BMD) and increases the risk of OA in women. The Ser37Ala (T/G) SNP is associated with BMD and the rate of bone loss in osteoporosis and osteoporosis fractures. A total of 57 OPLL patients and 135 non-OPLL controls were studied. Radiographs of the cervical spine were analyzed to determine the presence and the severity of OPLL. The association of two SNPs with the occurrence and the extent of OPLL were statistically evaluated. There was a significant association between the Ser37Ala (T/G) polymorphism and the occurrence of OPLL in the cervical spine. However, no significant association was found between the Ser37Ala (T/G) polymorphism and the more number of ossified cervical vertebrae in OPLL patients. There was a significant association between the Ser87Ser (A/G) polymorphism and the more number of ossified cervical vertebrae in OPLL patients. However, there was no statistical difference between the Ser87Ser (A/G) SNP and the occurrence of OPLL in the cervical spine. In addition, the Ser87Ser (A/G) polymorphism in male patients and in female patients showed no statistical difference between cases and controls. The present results demonstrate that BMP-2 Gene is not only a factor associated with the occurrence of OPLL, but also a factor related to more extensive OPLL. The “G” allele in the Ser37Ala (T/G) polymorphism is associated with the occurrence of OPLL, but not more extensive OPLL in the cervical spine. The “G” allele in the Ser87Ser (A/G) polymorphism promotes the extent of OPLL, whereas the “A” allele in the Ser87Ser (A/G) polymorphism restricts ectopic ossification in the cervical spine at least in Chinese subjects.
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影响因子：
9.8
作者：
Styrkarsdottir U;Cazier JB;Kong A;Rolfsson O;Larsen H;Bjarnadottir E;Johannsdottir VD;Sigurdardottir MS;Bagger Y;Christiansen C;Reynisdottir I;Grant SF;Jonasson K;Frigge ML;Gulcher JR;Sigurdsson G;Stefansson K
通讯作者：
Stefansson K
影响因子：
3.9
作者：
Heldin, CH;Eriksson, U;Östman, A
通讯作者：
Östman, A
影响因子：
3
作者：
Koga, H;Hayashi, K;Sakou, T
通讯作者：
Sakou, T
影响因子：
9.8
作者：
Koga, H;Sakou, T;Leppert, M
通讯作者：
Leppert, M
影响因子：
6.2
作者：
Maeda, S;Ishidou, Y;Inoue, I
通讯作者：
Inoue, I