Reduced cerebral blood flow in early stages of human immunodeficiency virus infection.

Reduced cerebral blood flow in early stages of human immunodeficiency virus infection.
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人类免疫缺陷病毒感染早期阶段脑血流量减少。

DOI:
10.1001/archneur.1990.00530120088015
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发表时间:
1990
影响因子:
--
通讯作者:
K. M. Einhäupl
K. M. Einhäupl
中科院分区:
--
文献类型:
--
作者:
E. Schielke;Klaus Tatsch;Hans Walter Pfister;C. Trenkwalder;G. Leinsinger;Carl Martin Kirsch;Alexander Matuschke;K. M. Einhäupl

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为了确定脑灌注异常是否发生在人类免疫缺陷病毒感染的早期阶段,这种情况已知存在于获得性免疫缺陷综合征痴呆症患者中,对20例Walter Reed期I至IV期感染人类免疫缺陷病毒的患者进行了锝99m六甲基丙烯胺肟单光子发射计算机断层扫描研究。这些患者均未表现出痴呆或严重神经功能障碍的迹象。14例患者出现六亚甲基-丙烯胺肟摄取的病理模式,其中7例在神经学检查中结果正常。仅4例患者在颅脑ct扫描上有脑萎缩征象。这些数据表明,脑灌注的细微变化似乎在人类免疫缺陷病毒感染过程的早期出现,可能在神经症状或明显的结构损伤发生之前表明人类免疫缺陷病毒脑病。
In order to determine if brain perfusion abnormalities, which are known in patients with acquiredimmunodeficiency syndrome dementia, occur in early stages of human immunodeficiency virus infection, technetium 99m hexamethyl-propyleneamine oxime-single-photon emission computed tomography studies were performed in 20 patients infected with human immunodeficiency virus who belonged to Walter Reed stages I through IV. None of these patients demonstrated signs of dementia or severe neurological dysfunction. Pathological patterns of hexamethyl-propyleneamine oxime uptake were seen in 14 patients, seven of whom had normal results during neurological examination. Only four patients had signs of cerebral atrophy on cranial computed tomographic scan. These data suggest that subtle changes in cerebral perfusion seem to arise early in the course of human immunodeficiency virus infection and may indicate human immunodeficiency virus encephalopathy before neurological symptoms or noticeable structural damage occurs.
固定组织切片中人类和猿猴免疫缺陷病毒抗原的免疫组织化学定位。
DOI: --
发表时间: 1987
期刊: The American journal of pathology
影响因子: --
作者:
Ward,JM;O'Leary,TJ;Baskin,GB;Benveniste,R;Harris,CA;Nara,PL;Rhodes,RH
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DOI: --
发表时间: 1986
期刊: Pediatrics
影响因子: 8
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Epstein,LG;Sharer,LR;Oleske,JM;Connor,EM;Goudsmit,J;Bagdon,L;Robert-Guroff,M;Koenigsberger,MR
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DOI: 10.1073/pnas.83.18.7089
发表时间: 1986-09-01
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通讯作者: OLDSTONE, MBA
获得性免疫缺陷综合征视网膜病变的微血管方面。
DOI: 10.1016/0002-9394(84)90245-9
发表时间: 1984
影响因子: 4.2
作者:
Newsome,DA;Green,WR;Miller,ED;Kiessling,LA;Morgan,B;Jabs,DA;Polk,BF
通讯作者: Polk,BF