Reduced cerebral blood flow in early stages of human immunodeficiency virus infection.
Reduced cerebral blood flow in early stages of human immunodeficiency virus infection.
复制标题
人类免疫缺陷病毒感染早期阶段脑血流量减少。
DOI:
10.1001/archneur.1990.00530120088015
复制
发表时间:
1990
影响因子:
--
通讯作者:
K. M. Einhäupl
中科院分区:
文献类型:
--
作者:
E. Schielke;Klaus Tatsch;Hans Walter Pfister;C. Trenkwalder;G. Leinsinger;Carl Martin Kirsch;Alexander Matuschke;K. M. Einhäupl
In order to determine if brain perfusion abnormalities, which are known in patients with acquiredimmunodeficiency syndrome dementia, occur in early stages of human immunodeficiency virus infection, technetium 99m hexamethyl-propyleneamine oxime-single-photon emission computed tomography studies were performed in 20 patients infected with human immunodeficiency virus who belonged to Walter Reed stages I through IV. None of these patients demonstrated signs of dementia or severe neurological dysfunction. Pathological patterns of hexamethyl-propyleneamine oxime uptake were seen in 14 patients, seven of whom had normal results during neurological examination. Only four patients had signs of cerebral atrophy on cranial computed tomographic scan. These data suggest that subtle changes in cerebral perfusion seem to arise early in the course of human immunodeficiency virus infection and may indicate human immunodeficiency virus encephalopathy before neurological symptoms or noticeable structural damage occurs.
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DOI:
--
发表时间:
1987
期刊:
The American journal of pathology
影响因子:
--
作者:
Ward,JM;O'Leary,TJ;Baskin,GB;Benveniste,R;Harris,CA;Nara,PL;Rhodes,RH
通讯作者:
Rhodes,RH
影响因子:
8
作者:
Epstein,LG;Sharer,LR;Oleske,JM;Connor,EM;Goudsmit,J;Bagdon,L;Robert-Guroff,M;Koenigsberger,MR
通讯作者:
Koenigsberger,MR
DOI:
10.1073/pnas.83.18.7089
发表时间:
1986-09-01
影响因子:
11.1
作者:
WILEY, CA;SCHRIER, RD;OLDSTONE, MBA
通讯作者:
OLDSTONE, MBA
影响因子:
4.2
作者:
Newsome,DA;Green,WR;Miller,ED;Kiessling,LA;Morgan,B;Jabs,DA;Polk,BF
通讯作者:
Polk,BF