Dependence between estrogen sulfotransferase (SULT1E1) and nuclear transcription factor Nrf-2 regulations via oxidative stress in breast cancer.
Dependence between estrogen sulfotransferase (SULT1E1) and nuclear transcription factor Nrf-2 regulations via oxidative stress in breast cancer.
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DOI：
10.1007/s11033-020-05518-z
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发表时间：
2020-06
影响因子：
2.8
通讯作者：
Maiti, Smarajit
中科院分区：
文献类型：
--
作者：
Nazmeen, Aarifa;Chen, Guangping;Maiti, Smarajit
Human estrogen sulfotransferase (SULT1E1) and nuclear factor erythroid 2-related factor 2 (Nrf-2) expression influences each other in advanced human breast carcinogenesis. The difference in the metabolism of estradiol (E2) in pre- and post-menopausal women remains to be connected with post-menopausal breast cancer. A synergism between ROS production and E2 generation has been demonstrated. No definite mechanism for simultaneous functions of Nrf2, oxidative stress E2 regulating enzymes (SULT1E1) has been yet clarified. Our present review demonstrates that ROS dependent regulation of Nrf-2 is one of the most important determinants of E2 regulation by altering SULT1E1 expression. This study also focuses the idea that estrogen receptor cased subtypes of cancer may have different molecular environments which has an impact on the therapeutic efficacy.
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作者：
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通讯作者：
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DOI：
10.3322/caac.21405
发表时间：
2017-09
期刊：
CA: a cancer journal for clinicians
影响因子：
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作者：
Picon-Ruiz M;Morata-Tarifa C;Valle-Goffin JJ;Friedman ER;Slingerland JM
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