Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention.
Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention.
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DOI：
10.3322/caac.21405
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发表时间：
2017-09
期刊：
影响因子：
--
通讯作者：
Slingerland JM
中科院分区：
文献类型：
--
作者：
Picon-Ruiz M;Morata-Tarifa C;Valle-Goffin JJ;Friedman ER;Slingerland JM
回答问题并获得 CME/CNE 近几十年来，肥胖人数空前增加，其对健康的影响也越来越明显。 2014年，全球有超过19亿成年人超重（体重指数[BMI]，25-29.9 kg/m2），其中超过6亿人肥胖（BMI ≥30 kg/m2）。尽管肥胖与糖尿病和冠状动脉疾病风险之间的关联众所周知，但肥胖对癌症发病率、发病率和死亡率的影响尚未得到充分认识。肥胖不仅与患乳腺癌的风险较高（尤其是绝经后女性）有关，而且与所有年龄段女性的疾病结局较差有关。本综述的第一部分总结了绝经前和绝经后女性以及激素受体阳性和阴性疾病患者中肥胖与乳腺癌发生和结局之间的关系。本综述的第二部分探讨了假设的分子机制见解，这些见解可能是肥胖影响增加局部和循环促炎细胞因子、促进肿瘤血管生成并刺激最恶性的癌症干细胞群以驱动癌症生长、侵袭和转移的影响的基础。最后，对观察性研究的回顾表明，增加体力活动与降低乳腺癌风险和更好的结果相关。还讨论了近期生活方式干预对减少性类固醇、胰岛素/胰岛素样生长因子-1 通路激活以及与肥胖患者乳腺癌预后较差相关的炎症生物标志物的影响。尽管许多观察性研究表明，减肥锻炼与改善乳腺癌预后相关，但仍需要进一步的前瞻性研究来确定减轻体重是否会改善患者预后。希望本文综述的几项正在进行的生活方式干预试验将支持将减肥干预策略系统地纳入乳腺癌患者的护理中。加州癌症临床杂志 2017 年；67：378–397。 © 2017 作者。 CA 由 Wiley periodicals, Inc. 代表美国癌症协会出版的《临床医生癌症杂志》。这是根据知识共享署名非商业许可条款的开放获取文章，允许在任何媒体中使用、分发和复制，前提是正确引用原始作品并且不将其用于商业目的。
Answer questions and earn CME/CNE Recent decades have seen an unprecedented rise in obesity, and the health impact thereof is increasingly evident. In 2014, worldwide, more than 1.9 billion adults were overweight (body mass index [BMI], 25‐29.9 kg/m2), and of these, over 600 million were obese (BMI ≥30 kg/m2). Although the association between obesity and the risk of diabetes and coronary artery disease is widely known, the impact of obesity on cancer incidence, morbidity, and mortality is not fully appreciated. Obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women, and with worse disease outcome for women of all ages. The first part of this review summarizes the relationships between obesity and breast cancer development and outcomes in premenopausal and postmenopausal women and in those with hormone receptor‐positive and ‐negative disease. The second part of this review addresses hypothesized molecular mechanistic insights that may underlie the effects of obesity to increase local and circulating proinflammatory cytokines, promote tumor angiogenesis and stimulate the most malignant cancer stem cell population to drive cancer growth, invasion, and metastasis. Finally, a review of observational studies demonstrates that increased physical activity is associated with lower breast cancer risk and better outcomes. The effects of recent lifestyle interventions to decrease sex steroids, insulin/insulin‐like growth factor‐1 pathway activation, and inflammatory biomarkers associated with worse breast cancer outcomes in obesity also are discussed. Although many observational studies indicate that exercise with weight loss is associated with improved breast cancer outcome, further prospective studies are needed to determine whether weight reduction will lead to improved patient outcomes. It is hoped that several ongoing lifestyle intervention trials, which are reviewed herein, will support the systematic incorporation of weight loss intervention strategies into care for patients with breast cancer. CA Cancer J Clin 2017;67:378–397. © 2017 The Authors. CA A Cancer Journal for Clinicians published by Wiley Periodicals, Inc. on behalf of American Cancer Society. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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影响因子：
--
作者：
Arcidiacono B;Iiritano S;Nocera A;Possidente K;Nevolo MT;Ventura V;Foti D;Chiefari E;Brunetti A
通讯作者：
Brunetti A
DOI：
10.1016/j.numecd.2009.02.006
发表时间：
2010-01
期刊：
Nutrition, metabolism, and cardiovascular diseases : NMCD
影响因子：
--
作者：
Agnoli C;Berrino F;Abagnato CA;Muti P;Panico S;Crosignani P;Krogh V
通讯作者：
Krogh V
影响因子：
168.9
作者：
Albain, K.;Anderson, S.;Arriagada, R.;Barlow, W.;Bergh, J.;Bliss, J.;Buyse, M.;Cameron, D.;Carrasco, E.;Clarke, M.;Correa, C.;Coates, A.;Collins, R.;Costantino, J.;Cutter, D.;Cuzick, J.;Darby, S.;Davidson, N.;Davies, C.;Davies, K.;Delmestri, A.;Di Leo, A.;Dowsett, M.;Elphinstone, P.;Evans, V.;Ewertz, M.;Gelber, R.;Gettins, L.;Geyer, C.;Goldhirsch, A.;Godwin, J.;Gray, R.;Gregory, C.;Hayes, D.;Hill, C.;Ingle, J.;Jakesz, R.;James, S.;Kaufmann, M.;Kerr, A.;MacKinnon, E.;McGale, P.;McHugh, T.;Norton, L.;Ohashi, Y.;Paik, S.;Pan, H. C.;Perez, E.;Peto, R.;Piccart, M.;Pierce, L.;Pritchard, K.;Pruneri, G.;Raina, V.;Ravdin, P.;Robertson, J.;Rutgers, E.;Shao, Y. F.;Swain, S.;Taylor, C.;Valagussa, P.;Viale, G.;Whelan, T.;Winer, E.;Wang, Y.;Wood, W.
通讯作者：
Wood, W.
影响因子：
11.5
作者：
Angelo, Laura S.;Kurzrock, Razelle
通讯作者：
Kurzrock, Razelle
DOI：
10.1073/pnas.101564798
发表时间：
2001-05-22
影响因子：
11.1
作者：
Cao, RH;Brakenhielm, E;Cao, YH
通讯作者：
Cao, YH