Inflammation and Atherosclerosis: Atherosclerotic Lesions in Takayasu Arteritis
Inflammation and Atherosclerosis: Atherosclerotic Lesions in Takayasu Arteritis
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炎症和动脉粥样硬化：大动脉炎的动脉粥样硬化病变
DOI：
10.1111/j.1749-6632.2000.tb06301.x
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发表时间：
2000
影响因子：
5.2
通讯作者：
Yasushi Kobayashi
中科院分区：
文献类型：
--
作者：
F. Numano;Y. Kishi;A. Tanaka;Miho Ohkawara;T. Kakuta;Yasushi Kobayashi
摘要：大动脉炎是一种慢性血管炎，主要累及主动脉及其主要分支以及冠状动脉和肺动脉，因动脉瘤样形成和/或破裂导致血栓形成或扩张而导致狭窄和/或阻塞。这些特征性异常是由于颈部血管阻塞导致视网膜动脉缺血所致。在西方国家，这种疾病也被称为“无脉症”，因为由于锁骨下动脉或臂动脉阻塞，脉搏常常消失。这种病态疾病的发病机制尚不清楚。在流行病学上，它主要在女性患者中发现，在亚洲和拉丁美洲国家更为流行。受影响的区域既有活跃的炎性病变，也有陈旧的纤维性病变。病毒感染和其他未知致病因素刺激的自身免疫过程可能在这些病理生理条件下发挥重要作用，因为HLA分析显示单倍型A24-B52-DR2在日本患者中有统计学意义的高频率。记录年轻女性大动脉炎患者的动脉粥样硬化并发症，她们通常没有传统的动脉粥样硬化危险因素，这可能是临床证据，表明炎症确实是动脉粥样硬化形成的重要危险因素。
Abstract: Takayasu arteritis is a chronic vasculitis, mainly involving the aorta and its main branches as well as the coronary and pulmonary arteries, causing stenosis and/or obstruction due to thrombus formation or dilatation due to aneurysmal formation and/or rupture of the involved arteries. These characteristic anomalies resulted from ischemia of retinal arteries due to the obstruction of cervical vessels. In Western countries this disease is also known as “pulseless disease,” because the pulse is frequently absent due to the obstruction of subclavian or brachial arteries. The pathogenesis of this morbid condition is still unknown. Epidemiologically, it is found mostly in female patients and is more prevalent in Asian and Latin American countries. Affected areas consist of a mixture of both active, productive inflammatory lesions, and old fibrous lesions. Autoimmune processes stimulated by viral infection and other unknown causative factors may play an important role under these pathophysiological conditions because HLA analysis revealed a statistically significant high frequency of haplotype A24‐B52‐DR2 in these patients in Japan. Documentation of atherosclerotic complications in young female patients with Takayasu arteritis who are generally free from traditional atherosclerosis risk factors may be clinical evidence that inflammation is indeed an important risk factor in atherogenesis.
影响因子：
15.9
作者：
Napoli, C;D'Armiento, FP;Palinski, W
通讯作者：
Palinski, W
动脉粥样硬化：免疫和脂质失衡的综合表现。
影响因子：
3.5
作者：
Wissler,RW;Group,PD
通讯作者：
Group,PD
影响因子：
3.5
作者：
Noguchi, S;Numano, F;Wilcox, JN
通讯作者：
Wilcox, JN