DNA Methylation and Resting Brain Function Mediate the Association between Childhood Urbanicity and Better Speed of Processing.
DNA Methylation and Resting Brain Function Mediate the Association between Childhood Urbanicity and Better Speed of Processing.
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DNA 甲基化和静息大脑功能介导了童年都市性和更快的处理速度之间的关联。
DOI：
10.1093/cercor/bhab117
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发表时间：
2021-08-26
期刊：
影响因子：
--
通讯作者：
Yan H
中科院分区：
文献类型：
--
作者：
Cheng W;Luo N;Zhang Y;Zhang X;Tan H;Zhang D;Sui J;Yue W;Yan H
城市化已被认为会影响认知，但潜在机制仍不明确。我们基于497名健康的中国成年人，检验了表观遗传修饰（DNA甲基化，DNAm）、脑白质纤维完整性（分数各向异性，FA）或局部自发脑功能活动（局部一致性，ReHo）是否在童年城市化与认知之间的关联中起作用。我们发现童年城市化与更好的认知表现之间存在显著相关性。多集典型相关分析（mCCA）确定了一个相互关联的DNAm - FA - ReHo三联体，其显示出显著的两两相关性（DNAm - FA：经邦费罗尼校正的P值，Pbon = 4.99E - 03，rho = 0.216；DNAm - ReHo：Pbon = 4.08E - 03，rho = 0.239；ReHo - FA：Pbon = 1.68E - 06，rho = 0.328）。因果中介分析显示：1）ReHo介导了童年城市化对加工速度10.86%的影响；2）童年城市化通过钙黏蛋白和Wnt信号通路中的DNA甲基化改变ReHo（中介效应：48.55%）。在一个独立队列中进一步验证了城市化影响加工速度时颞上回ReHo增加的中介效应。我们的研究表明ReHo，特别是颞上回脑活动的增加，在城市化相关的加工速度中具有中介作用。
Abstract Urbanicity has been suggested to affect cognition, but the underlying mechanism remains unknown. We examined whether epigenetic modification (DNA methylation, DNAm), and brain white matter fiber integrity (fractional anisotropy, FA) or local spontaneous brain function activity (regional homogeneity, ReHo) play roles in the association between childhood urbanicity and cognition based on 497 healthy Chinese adults. We found significant correlation between childhood urbanicity and better cognitive performance. Multiset canonical correlation analysis (mCCA) identified an intercorrelated DNAm-FA-ReHo triplet, which showed significant pairwise correlations (DNAm-FA: Bonferroni-adjusted P, Pbon = 4.99E−03, rho = 0.216; DNAm-ReHo: Pbon = 4.08E−03, rho = 0.239; ReHo-FA: Pbon = 1.68E−06, rho = 0.328). Causal mediation analysis revealed that 1) ReHo mediated 10.86% childhood urbanicity effects on the speed of processing and 2) childhood urbanicity alters ReHo through DNA methylation in the cadherin and Wnt signaling pathways (mediated effect: 48.55%). The mediation effect of increased ReHo in the superior temporal gyrus underlying urbanicity impact on a better speed of processing was further validated in an independent cohort. Our work suggests a mediation role for ReHo, particularly increased brain activity in the superior temporal gyrus, in the urbanicity-associated speed of processing.
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影响因子：
4.6
作者：
Fan, GP;Martinowich, K;Sun, YE
通讯作者：
Sun, YE
DOI：
10.1038/nrn.2018.1
发表时间：
2018-02-16
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Gilmore JH;Knickmeyer RC;Gao W
通讯作者：
Gao W
DOI：
10.1080/0969594x.2011.560562
发表时间：
2012-01-01
影响因子：
3.2
作者：
Chen, Yi-Hsin
通讯作者：
Chen, Yi-Hsin
影响因子：
2.7
作者：
KETTENRING, JR
通讯作者：
KETTENRING, JR
影响因子：
3.7
作者：
Hannon E;Lunnon K;Schalkwyk L;Mill J
通讯作者：
Mill J