Deficits in hippocampal-dependent memory across different rodent models of early life stress: systematic review and meta-analysis.
Deficits in hippocampal-dependent memory across different rodent models of early life stress: systematic review and meta-analysis.
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DOI：
10.1038/s41398-021-01352-4
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发表时间：
2021-04-20
影响因子：
6.8
通讯作者：
Kaffman A
中科院分区：
文献类型：
--
作者：
Rocha M;Wang D;Avila-Quintero V;Bloch MH;Kaffman A
暴露于早期生活压力（ELS）会导致啮齿动物和人类海马发育异常和功能缺陷，但尚未使用荟萃分析来量化不同啮齿动物ELS模型对海马依赖性记忆的影响。我们在PubMed和Web of Science中检索了评估处理、母亲分离（MS）和有限的寝具和嵌套（LBN）对Morris水迷宫（MWM）、新物体识别（NOR）和情境恐惧条件反射（CFC）中表现的影响的出版物。45项研究符合纳入标准（每项试验n = 451-763只啮齿动物），用于计算标准化平均差异（Hedge g），并评估异质性、发表偏倚以及性别和种属（大鼠与小鼠）的调节效应。我们发现LBN的异质性显著低于处理和MS，在三种范式中没有一致的性别或种属影响。LBN和MS在很大程度上依赖于背侧海马的任务中引起了类似的认知缺陷，如MWM和NOR，并且与暴露于处理的啮齿动物中观察到的改善的性能相比有显著差异。在CFC任务中，它更依赖于腹侧海马，所有三个范例显示减少冻结与中等的效果大小，没有统计学差异。这些研究结果表明，使用荟萃分析来量化大量不一致的临床前研究结果的实用性，并强调需要进一步研究处理导致背侧海马发生不同改变但与MS和LBN相比腹侧海马发生类似结果的可能性。
Exposure to early life stress (ELS) causes abnormal hippocampal development and functional deficits in rodents and humans, but no meta-analysis has been used yet to quantify the effects of different rodent models of ELS on hippocampal-dependent memory. We searched PubMed and Web of Science for publications that assessed the effects of handling, maternal separation (MS), and limited bedding and nesting (LBN) on performance in the Morris water maze (MWM), novel object recognition (NOR), and contextual fear conditioning (CFC). Forty-five studies met inclusion criteria (n = 451–763 rodents per test) and were used to calculate standardized mean differences (Hedge’s g) and to assess heterogeneity, publication bias, and the moderating effects of sex and species (rats vs. mice). We found significantly lower heterogeneity in LBN compared to handling and MS with no consistent effects of sex or species across the three paradigms. LBN and MS caused similar cognitive deficits in tasks that rely heavily on the dorsal hippocampus, such as MWM and NOR, and were significantly different compared to the improved performance seen in rodents exposed to handling. In the CFC task, which relies more on the ventral hippocampus, all three paradigms showed reduced freezing with moderate effect sizes that were not statistically different. These findings demonstrate the utility of using meta-analysis to quantify outcomes in a large number of inconsistent preclinical studies and highlight the need to further investigate the possibility that handling causes different alterations in the dorsal hippocampus but similar outcomes in the ventral hippocampus when compared to MS and LBN.
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影响因子：
5.1
作者：
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通讯作者：
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